SKF 91488 dihydrochloride

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Cat.No. 0512 - SKF 91488 dihydrochloride | C7H17N3S.2HCl | CAS No. 68941-21-9
Description: Histamine N-methyltransferase inhibitor
Chemical Name: 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride

Biological Activity

Homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.

Technical Data

M. Wt 248.21
Formula C7H17N3S.2HCl
Storage Desiccate at RT
CAS Number 68941-21-9
PubChem ID 11957708
Smiles CN(CCCCSC(=N)N)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.62 75

Preparing Stock Solutions

The following data is based on the product molecular weight 248.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.37 mL 26.86 mL 53.72 mL
3.75 mM 1.07 mL 5.37 mL 10.74 mL
7.5 mM 0.54 mL 2.69 mL 5.37 mL
37.5 mM 0.11 mL 0.54 mL 1.07 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References are publications that support the biological activity of the product.

Aiello et al (1997) Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 355 354 PMID: 9089666

Beaven and Shaff (1979) New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 28 183 PMID: 34400

Beaven and Shaff (1979) Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 9 455 PMID: 161853

Ohuri et al (1992) Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261 1268 PMID: 1534842

If you know of a relevant reference for SKF 91488 dihydrochloride, please let us know.

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