Dimaprit dihydrochloride

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Cat.No. 0506 - Dimaprit dihydrochloride | C6H15N3S.2HCl | CAS No. 23256-33-9
Description: Standard H2 selective agonist
Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (3)

Biological Activity

Selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).

Technical Data

M. Wt 234.19
Formula C6H15N3S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 23256-33-9
PubChem ID 90045
InChI Key DFWCPLGXFMSUCW-UHFFFAOYSA-N
Smiles CN(C)CCCSC(N)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 234.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.35 mL 42.7 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
10 mM 0.43 mL 2.14 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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References

References are publications that support the biological activity of the product.

Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39 PMID: 860674

Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276

Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331 PMID: 10385230

Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31 PMID: 871093


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Keywords: Dimaprit dihydrochloride, Dimaprit dihydrochloride supplier, H2, selective, agonists, Receptors, Histamine, histaminergic, 0506, Tocris Bioscience

3 Citations for Dimaprit dihydrochloride

Citations are publications that use Tocris products. Selected citations for Dimaprit dihydrochloride include:

Swartzendruber et al (2012) Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. Stem Cells Transl Med 188 536 PMID: 22156496

Fei et al (2009) Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol 296 G823 PMID: 19179625

Wang et al (2014) Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line. J Immunol 3 1126 PMID: 25045085


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