Dimaprit dihydrochloride

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Description: Standard H2 selective agonist
Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity for Dimaprit dihydrochloride

Dimaprit dihydrochloride is a selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).

Technical Data for Dimaprit dihydrochloride

M. Wt 234.19
Formula C6H15N3S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 23256-33-9
PubChem ID 90045
Smiles CN(C)CCCSC(N)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Dimaprit dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 23.42 100

Preparing Stock Solutions for Dimaprit dihydrochloride

The following data is based on the product molecular weight 234.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.35 mL 42.7 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
10 mM 0.43 mL 2.14 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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Product Datasheets for Dimaprit dihydrochloride

References for Dimaprit dihydrochloride

References are publications that support the biological activity of the product.

Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39 PMID: 860674

Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276

Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331 PMID: 10385230

Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31 PMID: 871093

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Keywords: Dimaprit dihydrochloride, Dimaprit dihydrochloride supplier, H2, selective, agonists, Receptors, Histamine, histaminergic, 0506, Tocris Bioscience

3 Citations for Dimaprit dihydrochloride

Citations are publications that use Tocris products. Selected citations for Dimaprit dihydrochloride include:

Fei et al (2009) Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol 296 G823 PMID: 19179625

Wang et al (2014) Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line. J Immunol 3 1126 PMID: 25045085

Swartzendruber et al (2012) Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. Stem Cells Transl Med 188 536 PMID: 22156496

Do you know of a great paper that uses Dimaprit dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.