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Selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 234.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.27 mL||21.35 mL||42.7 mL|
|5 mM||0.85 mL||4.27 mL||8.54 mL|
|10 mM||0.43 mL||2.14 mL||4.27 mL|
|50 mM||0.09 mL||0.43 mL||0.85 mL|
References are publications that support the biological activity of the product.
Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39 PMID: 860674
Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276
Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331 PMID: 10385230
Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31 PMID: 871093
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Keywords: Dimaprit dihydrochloride, Dimaprit dihydrochloride supplier, H2, selective, agonists, Receptors, Histamine, histaminergic, 0506, Tocris Bioscience
3 Citations for Dimaprit dihydrochloride
Citations are publications that use Tocris products. Selected citations for Dimaprit dihydrochloride include:
Swartzendruber et al (2012) Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. Stem Cells Transl Med 188 536 PMID: 22156496
Fei et al (2009) Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol 296 G823 PMID: 19179625
Wang et al (2014) Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line. J Immunol 3 1126 PMID: 25045085
Do you know of a great paper that uses Dimaprit dihydrochloride from Tocris? Please let us know.
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Literature in this Area
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