SKA 121

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Cat.No. 6398 - SKA 121 | C12H10N2O | CAS No. 1820708-73-3
Description: Positive allosteric modulator of KCa3.1 channels
Chemical Name: 5-Methylnaphth[2,1-d]oxazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50 = 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KV and NaV channels. Potentiates bradykinin-induced vasodilation ex vivo. Lowers mean arterial blood pressure in normotensive and hypertensive mice.

Technical Data

M. Wt 198.23
Formula C12H10N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1820708-73-3
PubChem ID 91827362
InChI Key JEGUERWMMMQFJV-UHFFFAOYSA-N
Smiles NC(O1)=NC2=C1C3=CC=CC=C3C(C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.82 100
ethanol 9.91 50

Preparing Stock Solutions

The following data is based on the product molecular weight 198.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.04 mL 25.22 mL 50.45 mL
5 mM 1.01 mL 5.04 mL 10.09 mL
10 mM 0.5 mL 2.52 mL 5.04 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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References

References are publications that support the biological activity of the product.

Coleman et al (2014) New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol.Pharmacol. 86 342 PMID: 24958817

Oliván-Viguera et al (2016) Vascular reactivity profile of novel KCa 3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 119 184 PMID: 26821335


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