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Submit ReviewSKA 121
Discontinued Product
6398 has been discontinued.
View all Calcium-Activated Potassium (K<sub>Ca</sub>) Channels products.
Description: Positive allosteric modulator of KCa3.1 (IK) channels
Chemical Name: 5-Methylnaphth[2,1-d]oxazol-2-amine
Purity: ≥98% (HPLC)
Biological Activity for SKA 121
SKA 121 is a positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50 = 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KV and NaV channels. Potentiates bradykinin-induced vasodilation ex vivo. Lowers mean arterial blood pressure in normotensive and hypertensive mice.
Technical Data for SKA 121
| M. Wt | 198.23 |
| Formula | C12H10N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1820708-73-3 |
| PubChem ID | 91827362 |
| InChI Key | JEGUERWMMMQFJV-UHFFFAOYSA-N |
| Smiles | NC(O1)=NC2=C1C3=CC=CC=C3C(C)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SKA 121
References for SKA 121
References are publications that support the biological activity of the product.
Coleman et al (2014) New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol.Pharmacol. 86 342 PMID: 24958817
Oliván-Viguera et al (2016) Vascular reactivity profile of novel KCa 3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 119 184 PMID: 26821335
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Citations for SKA 121
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Currently there are no citations for SKA 121.
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