Discontinued Product

SK1-I (Cat. No. 3711) has been withdrawn from sale for commercial reasons.
Description: Sphingosine kinase 1 (SphK1) inhibitor; antiproliferative
Chemical Name: 1,2,4-Trideoxy-4-(methylamino)-1-(4-pentylphenyl)-D-erythro-pent-1-enitol hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for SK1-I

Sphingosine kinase (SphK) inhibitor. Isoenzyme-selective for SphK1; displays no activity at SphK2. Also displays no inhibitory activity against a range of protein kinases including PKC, PKA, ERK1, EGFR and CDK2. Exhibits potent antileukemic activity in vivo; inhibits the growth of both U937 and Jurkat T cells. Also suppresses proliferation and induces apoptosis in several human glioblastoma cell lines.

Technical Data for SK1-I

M. Wt 313.86
Formula C17H27NO2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1072443-89-0
Smiles CCCCCC1=CC=C(/C=C/[C@H](O)[C@H](NC)CO)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SK1-I

Certificate of Analysis / Product Datasheet
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References for SK1-I

References are publications that support the biological activity of the product.

Kapitonov et al (2009) Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res. 69 6915 PMID: 19723667

Paugh et al (2009) Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells. J.Biol.Chem. 284 3408 PMID: 19074142

Paugh et al (2008) A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Neoplasia 112 1382

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Keywords: SK1-I, SK1-I supplier, sphingosine-1-phosphate, kinases, sphk1, inhibitors, inhibits, proapoptotic, antiproliferative, Sphingosine, Kinase, Other, Lipid, Metabolism, 3711, Tocris Bioscience

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