Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSphingosine kinase (SphK) inhibitor. Isoenzyme-selective for SphK1; displays no activity at SphK2. Also displays no inhibitory activity against a range of protein kinases including PKC, PKA, ERK1, EGFR and CDK2. Exhibits potent antileukemic activity in vivo; inhibits the growth of both U937 and Jurkat T cells. Also suppresses proliferation and induces apoptosis in several human glioblastoma cell lines.
M. Wt | 313.86 |
Formula | C17H27NO2.HCl |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 1072443-89-0 |
Smiles | CCCCCC1=CC=C(/C=C/[C@H](O)[C@H](NC)CO)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Kapitonov et al (2009) Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res. 69 6915 PMID: 19723667
Paugh et al (2009) Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells. J.Biol.Chem. 284 3408 PMID: 19074142
Paugh et al (2008) A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Neoplasia 112 1382
Keywords: SK1-I, SK1-I supplier, sphingosine-1-phosphate, kinases, sphk1, inhibitors, inhibits, proapoptotic, antiproliferative, Sphingosine, Kinase, Other, Lipid, Metabolism, 3711, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for SK1-I.
There are currently no reviews for this product. Be the first to review SK1-I and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image