Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSK1-I
Discontinued Product
SK1-I (Cat. No. 3711) has been withdrawn from sale for commercial reasons.
Description: Sphingosine kinase 1 (SphK1) inhibitor; antiproliferative
Chemical Name: 1,2,4-Trideoxy-4-(methylamino)-1-(4-pentylphenyl)-D-erythro-pent-1-enitol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SK1-I
Sphingosine kinase (SphK) inhibitor. Isoenzyme-selective for SphK1; displays no activity at SphK2. Also displays no inhibitory activity against a range of protein kinases including PKC, PKA, ERK1, EGFR and CDK2. Exhibits potent antileukemic activity in vivo; inhibits the growth of both U937 and Jurkat T cells. Also suppresses proliferation and induces apoptosis in several human glioblastoma cell lines.
Technical Data for SK1-I
| M. Wt | 313.86 |
| Formula | C17H27NO2.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1072443-89-0 |
| Smiles | CCCCCC1=CC=C(/C=C/[C@H](O)[C@H](NC)CO)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SK1-I
References for SK1-I
References are publications that support the biological activity of the product.
Kapitonov et al (2009) Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res. 69 6915 PMID: 19723667
Paugh et al (2009) Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells. J.Biol.Chem. 284 3408 PMID: 19074142
Paugh et al (2008) A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Neoplasia 112 1382
View Related Products by Target
View Related Products by Product Action
Keywords: SK1-I, SK1-I supplier, sphingosine-1-phosphate, kinases, sphk1, inhibitors, inhibits, proapoptotic, antiproliferative, Sphingosine, Kinase, Other, Lipid, Metabolism, 3711, Tocris Bioscience
Citations for SK1-I
Citations are publications that use Tocris products.
Currently there are no citations for SK1-I.
Reviews for SK1-I
There are currently no reviews for this product. Be the first to review SK1-I and earn rewards!
Have you used SK1-I?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis