Discontinued ProductUnfortunately SK1-I (Cat. No. 3711) has been withdrawn from sale for commercial reasons.
Sphingosine kinase (SphK) inhibitor. Isoenzyme-selective for SphK1; displays no activity at SphK2. Also displays no inhibitory activity against a range of protein kinases including PKC, PKA, ERK1, EGFR and CDK2. Exhibits potent antileukemic activity in vivo; inhibits the growth of both U937 and Jurkat T cells. Also suppresses proliferation and induces apoptosis in several human glioblastoma cell lines.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 313.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.19 mL||15.93 mL||31.86 mL|
|5 mM||0.64 mL||3.19 mL||6.37 mL|
|10 mM||0.32 mL||1.59 mL||3.19 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the products' biological activity.
Kapitonov et al (2009) Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res. 69 6915 PMID: 19723667
Paugh et al (2009) Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells. J.Biol.Chem. 284 3408 PMID: 19074142
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Keywords: SK1-I, supplier, sphingosine-1-phosphate, kinases, sphk1, inhibitors, inhibits, proapoptotic, antiproliferative, Sphingosine, Kinase, Other, Lipid, Metabolism, Sphingosine, Kinase, Tocris Bioscience
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