Siramesine hydrochloride

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Cat.No. 6740 - Siramesine hydrochloride | C30H31FN2O.HCl | CAS No. 224177-60-0
Description: High affinity σ agonist (σ2 > σ1)
Chemical Name: 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

High affinity σ receptor agonist (Ki values are 0.19 and 17 nM for σ2 and σ1 receptors, respectively). Displays anxiolytic and antidepressant effects in rodents. Also induces cell death in tumor cell lines.

Technical Data

M. Wt 491.04
Formula C30H31FN2O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 224177-60-0
PubChem ID 9891778
InChI Key ILSRGIFRZZSGPN-UHFFFAOYSA-N
Smiles FC1=CC=C(N2C=C(C3=CC=CC=C23)CCCCN4CCC5(OCC6=CC=CC=C56)CC4)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.55 50

Preparing Stock Solutions

The following data is based on the product molecular weight 491.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.07 mL 20.36 mL 40.73 mL
2.5 mM 0.81 mL 4.07 mL 8.15 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
25 mM 0.08 mL 0.41 mL 0.81 mL

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References

References are publications that support the biological activity of the product.

Søby et al (2002) Lu 28-179 labels a σ2-site in rat and human brain. Neuropharmacology. 43 95 PMID: 12213263

Sánchez et al (1997) The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J.Pharmacol.Exp.Ther. 283 1323 PMID: 9400007

Česen et al (2013) Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Des. 4 e818 PMID: 24091661


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Citations for Siramesine hydrochloride

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