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Submit ReviewSiramesine hydrochloride
Description: High affinity σ agonist (σ2 > σ1)
Chemical Name: 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity
High affinity σ receptor agonist (Ki values are 0.19 and 17 nM for σ2 and σ1 receptors, respectively). Displays anxiolytic and antidepressant effects in rodents. Also induces cell death in tumor cell lines.
Technical Data
| M. Wt | 491.04 |
| Formula | C30H31FN2O.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 224177-60-0 |
| PubChem ID | 9891778 |
| InChI Key | ILSRGIFRZZSGPN-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(N2C=C(C3=CC=CC=C23)CCCCN4CCC5(OCC6=CC=CC=C56)CC4)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.55 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 491.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.07 mL | 20.36 mL | 40.73 mL |
| 2.5 mM | 0.81 mL | 4.07 mL | 8.15 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.07 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.81 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Søby et al (2002) Lu 28-179 labels a σ2-site in rat and human brain. Neuropharmacology. 43 95 PMID: 12213263
Sánchez et al (1997) The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J.Pharmacol.Exp.Ther. 283 1323 PMID: 9400007
Česen et al (2013) Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Des. 4 e818 PMID: 24091661
If you know of a relevant reference for Siramesine hydrochloride, please let us know.
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Keywords: Siramesine hydrochloride, Siramesine hydrochloride supplier, Lu, 28-179, sigma2, agonists, agonism, high, affinity, cell, death, inducers, σ2, σ1, sigma1, Sigma2, Receptors, 6740, Tocris Bioscience
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