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Submit ReviewSiramesine hydrochloride
Discontinued Product
6740 has been discontinued.
Description: High affinity σ agonist (σ2 > σ1)
Chemical Name: 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Siramesine hydrochloride
Siramesine hydrochloride is a high affinity σ receptor agonist (Ki values are 0.19 and 17 nM for σ2 and σ1 receptors, respectively). Displays anxiolytic and antidepressant effects in rodents. Also induces cell death in tumor cell lines.
Technical Data for Siramesine hydrochloride
| M. Wt | 491.04 |
| Formula | C30H31FN2O.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 224177-60-0 |
| PubChem ID | 9891778 |
| InChI Key | ILSRGIFRZZSGPN-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(N2C=C(C3=CC=CC=C23)CCCCN4CCC5(OCC6=CC=CC=C56)CC4)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Siramesine hydrochloride
References for Siramesine hydrochloride
References are publications that support the biological activity of the product.
Søby et al (2002) Lu 28-179 labels a σ2-site in rat and human brain. Neuropharmacology. 43 95 PMID: 12213263
Sánchez et al (1997) The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J.Pharmacol.Exp.Ther. 283 1323 PMID: 9400007
Česen et al (2013) Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Des. 4 e818 PMID: 24091661
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Keywords: Siramesine hydrochloride, Siramesine hydrochloride supplier, Lu, 28-179, sigma2, agonists, agonism, high, affinity, cell, death, inducers, σ2, σ1, sigma1, Sigma2, Receptors, 6740, Tocris Bioscience
Citations for Siramesine hydrochloride
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Currently there are no citations for Siramesine hydrochloride.
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