You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
High affinity σ receptor agonist (Ki values are 0.19 and 17 nM for σ2 and σ1 receptors, respectively). Displays anxiolytic and antidepressant effects in rodents. Also induces cell death in tumor cell lines.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 491.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.07 mL||20.36 mL||40.73 mL|
|2.5 mM||0.81 mL||4.07 mL||8.15 mL|
|5 mM||0.41 mL||2.04 mL||4.07 mL|
|25 mM||0.08 mL||0.41 mL||0.81 mL|
References are publications that support the biological activity of the product.
Søby et al (2002) Lu 28-179 labels a σ2-site in rat and human brain. Neuropharmacology. 43 95 PMID: 12213263
Sánchez et al (1997) The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J.Pharmacol.Exp.Ther. 283 1323 PMID: 9400007
Česen et al (2013) Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Des. 4 e818 PMID: 24091661
If you know of a relevant reference for Siramesine hydrochloride, please let us know.
View Related Products by Product Action
Keywords: Siramesine hydrochloride, Siramesine hydrochloride supplier, Lu, 28-179, sigma2, agonists, agonism, high, affinity, cell, death, inducers, σ2, σ1, sigma1, Sigma2, Receptors, 6740, Tocris Bioscience
Citations for Siramesine hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Siramesine hydrochloride. Do you know of a great paper that uses Siramesine hydrochloride from Tocris? Please let us know.
Reviews for Siramesine hydrochloride
There are currently no reviews for this product. Be the first to review Siramesine hydrochloride and earn rewards!
Have you used Siramesine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.