Silibinin

Discontinued Product

Silibinin (Cat. No. 0637) has been withdrawn from sale for commercial reasons.
Cat.No. 0637 - Silibinin | CAS No. 22888-70-6
Description: Induces G1 arrest
Chemical Name: [2R-[2a,3b,6(2R*,3R*)]]-2-[2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Datasheet
Citations
Reviews
Literature

Biological Activity

The active principle from Silybum marianum. Used for treatment of liver damage.

Technical Data

M. Wt 482.44
Storage Store at RT
CAS Number 22888-70-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

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Safety Datasheet

References

References are publications that support the biological activity of the product.

Sonnenbichler et al (1986) Stimulatory effect of silbinin on the DNA synthesis in partially hepatectomized rat livers: non-response in hematoma and other malign cell lines. Biochem.Pharmacol. 35 538 PMID: 3004503

Sonnenbichler et al (1999) Stimulatory effects of silibinin and silicristin from the milk thistle silybum marianum on kidney cells. J.Pharmacol.Exp.Ther. 290 1375 PMID: 10454517

Zi and Agarwal (1999) Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implication for prostate cancer intervention. Proc.Natl.Acad.Sci.U.S.A. 96 7490 PMID: 10377442

Martindale 29th Ed. 1613

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.