Siguazodan

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Cat.No. 1148 - Siguazodan | C14H16N6O | CAS No. 115344-47-3
Description: PDE3 inhibitor
Chemical Name: N-Cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Phosphodiesterase inhibitor, selective for PDE3 (IC50 = 117 nM).

Technical Data

M. Wt 284.32
Formula C14H16N6O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 115344-47-3
PubChem ID 72124
InChI Key NUHPODZZKHQQET-UHFFFAOYSA-N
Smiles CN\C(NC#N)=N/C1=CC=C(C=C1)C1=NNC(=O)CC1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions

The following data is based on the product molecular weight 284.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.59 mL 35.17 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Freitag et al (1998) Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from trachea of newborn rabbits. Eur.J.Pharmacol. 354 67 PMID: 9726632

Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105 PMID: 7925608

Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185


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Keywords: Siguazodan, Siguazodan supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, 1148, Tocris Bioscience

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