Siguazodan
Biological Activity
Phosphodiesterase inhibitor, selective for PDE3 (IC50 = 117 nM).
Compound Libraries
Siguazodan is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 284.32 |
| Formula | C14H16N6O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 115344-47-3 |
| PubChem ID | 72124 |
| InChI Key | NUHPODZZKHQQET-UHFFFAOYSA-N |
| Smiles | CN\C(NC#N)=N/C1=CC=C(C=C1)C1=NNC(=O)CC1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 284.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.03 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Freitag et al (1998) Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from trachea of newborn rabbits. Eur.J.Pharmacol. 354 67 PMID: 9726632
Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105 PMID: 7925608
Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185 PMID:
If you know of a relevant reference for Siguazodan, please let us know.
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Keywords: PDE3 inhibitors inhibits Phosphodiesterases Phosphodiesterases
Citations for Siguazodan
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