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Submit ReviewSiguazodan
Description: PDE3 inhibitor
Chemical Name: N-Cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
Purity: ≥99% (HPLC)
Biological Activity for Siguazodan
Siguazodan is a phosphodiesterase inhibitor, selective for PDE3 (IC50 = 117 nM).
Technical Data for Siguazodan
| M. Wt | 284.32 |
| Formula | C14H16N6O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 115344-47-3 |
| PubChem ID | 72124 |
| InChI Key | NUHPODZZKHQQET-UHFFFAOYSA-N |
| Smiles | CN\C(NC#N)=N/C1=CC=C(C=C1)C1=NNC(=O)CC1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Siguazodan
References for Siguazodan
References are publications that support the biological activity of the product.
Freitag et al (1998) Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from trachea of newborn rabbits. Eur.J.Pharmacol. 354 67 PMID: 9726632
Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105 PMID: 7925608
Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185
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Keywords: Siguazodan, Siguazodan supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, 1148, Tocris Bioscience
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