SID 7969543

Pricing Availability Delivery Time Qty
Cat.No. 3440 - SID 7969543 | C24H24N2O7 | CAS No. 868224-64-0
Description: Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor
Chemical Name: Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).

Compound Libraries

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Technical Data

M. Wt 452.46
Formula C24H24N2O7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 868224-64-0
PubChem ID 4076092
InChI Key KWMBIIQCLUIHDI-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC(OC(C)C(OCC)=O)=C1C=CN2CC(NC3=CC=C(OCCO4)C4=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 452.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Roth et al (2008) Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 18 2628 PMID: 18374567

Madoux et al (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 73 1776 PMID: 18334597


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Keywords: Selective steroidogenic factor-1 SF-1 NR5A1 inhibitors inhibits Nuclear Receptors Steroidogenic Factor-1 SID7969543 Other Nuclear Receptors

Citations for SID 7969543

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Literature in this Area

Cancer

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A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Pathways for SID 7969543

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