SID 7969543

Pricing Availability   Qty
Description: Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor
Chemical Name: Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for SID 7969543

SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).

Technical Data for SID 7969543

M. Wt 452.46
Formula C24H24N2O7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 868224-64-0
PubChem ID 4076092
Smiles O=C2C1=CC=CC(OC(C)C(OCC)=O)=C1C=CN2CC(NC3=CC=C(OCCO4)C4=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SID 7969543

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.25 100

Preparing Stock Solutions for SID 7969543

The following data is based on the product molecular weight 452.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for SID 7969543

References are publications that support the biological activity of the product.

Roth et al (2008) Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. 18 2628 PMID: 18374567

Madoux et al (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 73 1776 PMID: 18334597

If you know of a relevant reference for SID 7969543, please let us know.

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Keywords: SID 7969543, SID 7969543 supplier, Selective, steroidogenic, factor-1, SF-1, NR5A1, inhibitors, inhibits, Nuclear, Receptors, Steroidogenic, Factor-1, SID7969543, Other, 3440, Tocris Bioscience

1 Citation for SID 7969543

Citations are publications that use Tocris products. Selected citations for SID 7969543 include:

Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734

Do you know of a great paper that uses SID 7969543 from Tocris? Please let us know.

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Literature in this Area

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