SHIP 2a
Biological Activity
Cystathione γ lyase (CSE) inhibitor (IC50 = 6.3 μM). Inhibits H2S production in mouse aorta homogenates and L-cysteine-induced relaxation of rat aortic rings ex vivo.
Technical Data
| M. Wt | 184.22 |
| Formula | C7H8N2O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 124221753 |
| InChI Key | MWEQVHWJNCRXGP-YFKPBYRVSA-N |
| Smiles | O=C([C@@H]1CSC(N1)=O)NCC#C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 9.21 | 50 | |
| DMSO | 18.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 184.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.43 mL | 27.14 mL | 54.28 mL |
| 5 mM | 1.09 mL | 5.43 mL | 10.86 mL |
| 10 mM | 0.54 mL | 2.71 mL | 5.43 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.09 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Corvino et al (2016) Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci.Rep. 6 34398 PMID: 27708394
If you know of a relevant reference for SHIP 2a, please let us know.
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