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Cat.No. 6101 - SHIP 2a | C7H8N2O2S | CAS No. 2165706-30-7
Description: Cystathione γ lyase (CSE) inhibitor
Chemical Name: (R)-2-Oxo-N-2-propyn-1-yl-4-thiazolidinecarboxamide
Purity: ≥98% (HPLC)

Biological Activity for SHIP 2a

SHIP 2a is a cystathione γ lyase (CSE) inhibitor (IC50 = 6.3 μM). Inhibits H2S production in mouse aorta homogenates and L-cysteine-induced relaxation of rat aortic rings ex vivo.

Technical Data for SHIP 2a

M. Wt 184.22
Formula C7H8N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2165706-30-7
PubChem ID 124221753
Smiles O=C([C@@H]1CSC(N1)=O)NCC#C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SHIP 2a

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.42 100
ethanol 9.21 50

Preparing Stock Solutions for SHIP 2a

The following data is based on the product molecular weight 184.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.43 mL 27.14 mL 54.28 mL
5 mM 1.09 mL 5.43 mL 10.86 mL
10 mM 0.54 mL 2.71 mL 5.43 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

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References for SHIP 2a

References are publications that support the biological activity of the product.

Corvino et al (2016) Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci.Rep. 6 34398 PMID: 27708394

If you know of a relevant reference for SHIP 2a, please let us know.

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Keywords: SHIP 2a, SHIP 2a supplier, SHIP2a, cystathionase, cystathione, gamma, lyase, CSE, γ, inhibitors, inhibits, hydrogen, sulphide, sulfide, H2S, Other, Lyases, 6101, Tocris Bioscience

Citations for SHIP 2a

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