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SHIP 2a

Cat. No. 6101 Submit a Review Datasheet / COA / SDS
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Cat.No. 6101 - SHIP 2a | C7H8N2O2S | CAS No. 2165706-30-7
Description: Cystathione γ lyase (CSE) inhibitor
Chemical Name: (R)-2-Oxo-N-2-propyn-1-yl-4-thiazolidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cystathione γ lyase (CSE) inhibitor (IC50 = 6.3 μM). Inhibits H2S production in mouse aorta homogenates and L-cysteine-induced relaxation of rat aortic rings ex vivo.

Technical Data

M. Wt 184.22
Formula C7H8N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2165706-30-7
PubChem ID 124221753
InChI Key MWEQVHWJNCRXGP-YFKPBYRVSA-N
Smiles O=C([C@@H]1CSC(N1)=O)NCC#C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.42 100
ethanol 9.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 184.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.43 mL 27.14 mL 54.28 mL
5 mM 1.09 mL 5.43 mL 10.86 mL
10 mM 0.54 mL 2.71 mL 5.43 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

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References

References are publications that support the biological activity of the product.

Corvino et al (2016) Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci.Rep. 6 34398 PMID: 27708394

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