SHIP 2a
Biological Activity
Cystathione γ lyase (CSE) inhibitor (IC50 = 6.3 μM). Inhibits H2S production in mouse aorta homogenates and L-cysteine-induced relaxation of rat aortic rings ex vivo.
Technical Data
| M. Wt | 184.22 |
| Formula | C7H8N2O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 124221753 |
| InChI Key | MWEQVHWJNCRXGP-YFKPBYRVSA-N |
| Smiles | O=C([C@@H]1CSC(N1)=O)NCC#C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.42 | 100 | |
| ethanol | 9.21 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 184.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.43 mL | 27.14 mL | 54.28 mL |
| 5 mM | 1.09 mL | 5.43 mL | 10.86 mL |
| 10 mM | 0.54 mL | 2.71 mL | 5.43 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.09 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Corvino et al (2016) Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci.Rep. 6 34398 PMID: 27708394
If you know of a relevant reference for SHIP 2a, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SHIP 2a, SHIP 2a supplier, SHIP2a, cystathionase, cystathione, gamma, lyase, CSE, γ, inhibitors, inhibits, hydrogen, sulphide, sulfide, H2S, Other, Lyases, 6101, Tocris Bioscience
Citations for SHIP 2a
Citations are publications that use Tocris products.
Currently there are no citations for SHIP 2a. Do you know of a great paper that uses SHIP 2a from Tocris? Please let us know.
Reviews for SHIP 2a
There are currently no reviews for this product. Be the first to review SHIP 2a and earn rewards!
Have you used SHIP 2a?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)New
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Chemogenetics
- Epigenetics
- Fluorescent Imaging
- PROTACs
- Signal Transduction
- Stem Cells
