SHIP 2a

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Cat.No. 6101 - SHIP 2a | C7H8N2O2S
Description: Cystathione γ lyase (CSE) inhibitor
Chemical Name: (R)-2-Oxo-N-2-propyn-1-yl-4-thiazolidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Cystathione γ lyase (CSE) inhibitor (IC50 = 6.3 μM). Inhibits H2S production in mouse aorta homogenates and L-cysteine-induced relaxation of rat aortic rings ex vivo.

Technical Data

M. Wt 184.22
Formula C7H8N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 124221753
InChI Key MWEQVHWJNCRXGP-YFKPBYRVSA-N
Smiles O=C([C@@H]1CSC(N1)=O)NCC#C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 9.21 50
DMSO 18.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 184.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.43 mL 27.14 mL 54.28 mL
5 mM 1.09 mL 5.43 mL 10.86 mL
10 mM 0.54 mL 2.71 mL 5.43 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

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References

References are publications that support the biological activity of the product.

Corvino et al (2016) Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci.Rep. 6 34398 PMID: 27708394


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Citations for SHIP 2a

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