Home / Pharmacology / Enzymes / Lyases / Other Lyases / Other Lyase Inhibitors / SHIP 2a

SHIP 2a

Cat. No. 6101 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 6101 - SHIP 2a | C7H8N2O2S | CAS No. 2165706-30-7
Description: Cystathione γ lyase (CSE) inhibitor
Chemical Name: (R)-2-Oxo-N-2-propyn-1-yl-4-thiazolidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SHIP 2a

SHIP 2a is a cystathione γ lyase (CSE) inhibitor (IC50 = 6.3 μM). Inhibits H2S production in mouse aorta homogenates and L-cysteine-induced relaxation of rat aortic rings ex vivo.

Technical Data for SHIP 2a

M. Wt 184.22
Formula C7H8N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2165706-30-7
PubChem ID 124221753
InChI Key MWEQVHWJNCRXGP-YFKPBYRVSA-N
Smiles O=C([C@@H]1CSC(N1)=O)NCC#C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SHIP 2a

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.42 100
ethanol 9.21 50

Preparing Stock Solutions for SHIP 2a

The following data is based on the product molecular weight 184.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.43 mL 27.14 mL 54.28 mL
5 mM 1.09 mL 5.43 mL 10.86 mL
10 mM 0.54 mL 2.71 mL 5.43 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for SHIP 2a

References are publications that support the biological activity of the product.

Corvino et al (2016) Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci.Rep. 6 34398 PMID: 27708394

If you know of a relevant reference for SHIP 2a, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Lyase Inhibitors

Keywords: SHIP 2a, SHIP 2a supplier, SHIP2a, cystathionase, cystathione, gamma, lyase, CSE, γ, inhibitors, inhibits, hydrogen, sulphide, sulfide, H2S, Other, Lyases, 6101, Tocris Bioscience

Citations for SHIP 2a

Citations are publications that use Tocris products.

Currently there are no citations for SHIP 2a. Do you know of a great paper that uses SHIP 2a from Tocris? Please let us know.

Reviews for SHIP 2a

There are currently no reviews for this product. Be the first to review SHIP 2a and earn rewards!

Have you used SHIP 2a?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review