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SHA 68

Cat. No. 4510 Submit a Review Datasheet / COA / SDS
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Cat.No. 4510 - SHA 68 | C26H24FN3O3 | CAS No. 847553-89-3
Description: Selective Neuropeptide S receptor antagonist
Chemical Name: N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective neuropeptide S receptor (NPSR) antagonist (IC50 values are 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively). Displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors.

Compound Libraries

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Technical Data

M. Wt 445.49
Formula C26H24FN3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 847553-89-3
PubChem ID 11374217
InChI Key SFRQIPRTNYHJHP-UHFFFAOYSA-N
Smiles O=C(NCC4=CC=C(F)C=C4)N1CC2N(C(OC(C5=CC=CC=C5)2C3=CC=CC=C3)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.55 100
ethanol 44.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 445.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.45 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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References

References are publications that support the biological activity of the product.

Okamura et al (2008) Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor. J.Pharmacol.Exp.Ther. 325 893 PMID: 18337476

Okamura et al (2011) Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain. Neuropsychopharmacology 36 744 PMID: 21150909

Trapella et al (2011) Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68). J.Med.Chem. 54 2738 PMID: 21466221

If you know of a relevant reference for SHA 68, please let us know.

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Keywords: SHA 68, SHA 68 supplier, SHA68, neuropeptides, S, NPSRs, NPS, antagonists, selective, Neuropeptide, Receptors, 4510, Tocris Bioscience

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