SHA 68

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Description: Selective Neuropeptide S receptor antagonist
Chemical Name: N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for SHA 68

SHA 68 is a selective neuropeptide S receptor (NPSR) antagonist (IC50 values are 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively). Displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors.

Compound Libraries for SHA 68

SHA 68 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SHA 68

M. Wt 445.49
Formula C26H24FN3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 847553-89-3
PubChem ID 11374217
InChI Key SFRQIPRTNYHJHP-UHFFFAOYSA-N
Smiles O=C(NCC4=CC=C(F)C=C4)N1CC2N(C(OC(C5=CC=CC=C5)2C3=CC=CC=C3)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SHA 68

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.55 100
ethanol 44.55 100

Preparing Stock Solutions for SHA 68

The following data is based on the product molecular weight 445.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.45 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Keywords: SHA 68, SHA 68 supplier, SHA68, neuropeptides, S, NPSRs, NPS, antagonists, selective, Neuropeptide, Receptors, 4510, Tocris Bioscience

2 Citations for SHA 68

Citations are publications that use Tocris products. Selected citations for SHA 68 include:

Ruzza et al (2018) Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies. Pharmacol Res Perspect 6 e00445 PMID: 30534379

Jing et al (2020) Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory. Chem Senses 45 195-202 PMID: 32010937


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