SGC 3027N

Pricing Availability   Qty
Description: Negative control for SGC 3027 (Cat. No. 6825)
Chemical Name: N-(4-((((3aS,4S,6R,6aR)-6-(6-Amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)thio)butyl)-N-((4'-chloro-[1,1'-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for SGC 3027N

SGC 3027N is a negative control for SGC 3027 (Cat. No. 6825).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 3027 probe summary on the SGC website.

Technical Data for SGC 3027N

M. Wt 827.43
Formula C44H51ClN6O6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2624313-14-8
Smiles ClC1=CC=C(C2=CC(CN(CCCCSC[C@H]3O[C@@H](N4C=NC5=C4N=CN=C5N)[C@H]6[C@@H]3OC(C)(C)O6)C(CC(C7=C(C)C(C(C)=C(C)C7=O)=O)(C)C)=O)=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SGC 3027N

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 82.74 100
ethanol 8.27 10

Preparing Stock Solutions for SGC 3027N

The following data is based on the product molecular weight 827.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.21 mL 6.04 mL 12.09 mL
5 mM 0.24 mL 1.21 mL 2.42 mL
10 mM 0.12 mL 0.6 mL 1.21 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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References for SGC 3027N

References are publications that support the biological activity of the product.

Szewczy et al (2020) Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nat.Commun. 11 2396 PMID: 32409666

If you know of a relevant reference for SGC 3027N, please let us know.

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Citations for SGC 3027N

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.