SGC 3027

Pricing Availability   Qty
Cat.No. 6825 - SGC 3027 | C41H47ClN6O6S
Description: Potent and selective PRMT7 inhibitor
Chemical Name: N-(4-((((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butyl)-N-((4'-chloro-[1,1'-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent and selective PRMT7 inhibitor (IC50 < 2.5 nM); pro-drug of SGC 8158. Methylates H2B (23-37). Exhibits > 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits methylation of HSP70 in C2C12 cells.

Negative control, SGC 3027N (Cat. No. 6838) also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 3027 probe summary on the SGC website.

Technical Data

M. Wt 787.37
Formula C41H47ClN6O6S
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 137333447
InChI Key MLJVGAYSVYMPSB-MSUKGTQXSA-N
Smiles ClC1=CC=C(C2=CC(CN(CCCCSC[C@H]3O[C@@H](N4C=NC5=C4N=CN=C5N)[C@H](O)[C@@H]3O)C(CC(C6=C(C)C(C(C)=C(C)C6=O)=O)(C)C)=O)=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 787.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.27 mL 6.35 mL 12.7 mL
5 mM 0.25 mL 1.27 mL 2.54 mL
10 mM 0.13 mL 0.64 mL 1.27 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Szewczyk et al (2020) Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress responses. Nat.Commun. 11 2396 PMID: 32409666


If you know of a relevant reference for SGC 3027, please let us know.

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View all Protein Arginine Methyltransferase Inhibitors

Keywords: SGC 3027, SGC 3027 supplier, SGC3027, Potent, selective, PRMT7, inhibitors, inhibits, Protein, Arginine, Methyltransferases, 6825, Tocris Bioscience

Citations for SGC 3027

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases