SER 601

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Cat.No. 3556 - SER 601 | C28H38N2O2 | CAS No. 1048038-90-9
Description: Potent, selective CB2 agonist
Alternative Names: COR 167
Chemical Name: N-(Adamant-1-yl)-6-isopropyl-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective CB2 receptor agonist (Ki values are 6.3 nM and 1.2 μM for CB2 and CB1 receptors respectively). Displays analgesic activity in the formalin test in mice.

Technical Data

M. Wt 434.61
Formula C28H38N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1048038-90-9
PubChem ID 25034551
InChI Key KUMKLUDNETVLDS-UHFFFAOYSA-N
Smiles O=C(C4=CN(CCCCC)C5=C(C=C(C(C)C)C=C5)C4=O)NC12CC(C3)CC(CC3C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.87 25
ethanol 21.73 50

Preparing Stock Solutions

The following data is based on the product molecular weight 434.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.6 mL 23.01 mL 46.02 mL
2.5 mM 0.92 mL 4.6 mL 9.2 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

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References

References are publications that support the biological activity of the product.

Pasquini et al (2008) Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo. J.Med.Chem. 51 5075 PMID: 18680276

Contartese (2012) A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacol.Res. 66 555 PMID: 23036353


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Keywords: SER 601, SER 601 supplier, Potent, selective, CB2, receptors, agonists, analgesic, cannabinoids, SER601, cb2r, COR, 167, COR167, Receptors, 3556, Tocris Bioscience

1 Citation for SER 601

Citations are publications that use Tocris products. Selected citations for SER 601 include:

Blaha et al (2016) Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. PLoS One 11 e0157424 PMID: 27285468


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