Senexin A

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Description: Cdk8 inhibitor
Chemical Name: 4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews

Biological Activity for Senexin A

Senexin A is a cyclin-dependent kinase 8 (cdk8) inhibitor (IC50 = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin-induced tumor-promoting paracrine activities in vivo.

Licensing Information

Sold under license from Senex Biotechnology.

Technical Data for Senexin A

M. Wt 310.78
Formula C17H14N4.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1780390-76-2
PubChem ID 90488980
InChI Key POENYXHGUHRXFR-UHFFFAOYSA-N
Smiles N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Senexin A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.08 100

Preparing Stock Solutions for Senexin A

The following data is based on the product molecular weight 310.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.09 mL 32.18 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets for Senexin A

Certificate of Analysis / Product Datasheet
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References for Senexin A

References are publications that support the biological activity of the product.

Porter et al (2012) Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc.Natl.Acad.Sci.U.S.A. 109 13799 PMID: 22869755


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Keywords: Senexin A, Senexin A supplier, cyclin, dependent, kinases, cdks, cdk8, cdk19, inhibits, inhibitors, p21, transcription, Cyclin-dependent, Kinase, Transcriptional, CDKs, 4875, Tocris Bioscience

5 Citations for Senexin A

Citations are publications that use Tocris products. Selected citations for Senexin A include:

Jing et al (2019) CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. Cell Rep 28 2892-2904.e7 PMID: 31509750

Tang et al (2018) The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming. Cell Metab 27 1040 PMID: 29606597

Rebecca et al (2020) Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism. Viruses 12 PMID: 32183180

Katrina F et al (2020) The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription. J Biol Chem 295 16280-16291 PMID: 32934007


Do you know of a great paper that uses Senexin A from Tocris? Please let us know.

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