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Submit ReviewSenexin A
Description: Cdk8 inhibitor
Chemical Name: 4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Cyclin-dependent kinase 8 (cdk8) inhibitor (IC50 = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin-induced tumor-promoting paracrine activities in vivo.
Licensing Information
Sold under license from Senex Biotechnology.
Technical Data
| M. Wt | 310.78 |
| Formula | C17H14N4.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 90488980 |
| InChI Key | POENYXHGUHRXFR-UHFFFAOYSA-N |
| Smiles | N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.08 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 310.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.22 mL | 16.09 mL | 32.18 mL |
| 5 mM | 0.64 mL | 3.22 mL | 6.44 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.22 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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References
References are publications that support the biological activity of the product.
Porter et al (2012) Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc.Natl.Acad.Sci.U.S.A. 109 13799 PMID: 22869755
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Keywords: Senexin A, Senexin A supplier, cyclin, dependent, kinases, cdks, cdk8, cdk19, inhibits, inhibitors, p21, transcription, Cyclin-dependent, Kinase, 4875, Tocris Bioscience
2 Citations for Senexin A
Citations are publications that use Tocris products. Selected citations for Senexin A include:
Brägelmann et al (2017) Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer. Clin Cancer Res 23 1829 PMID: 27678455
Tang et al (2018) The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming. Cell Metab 27 1040 PMID: 29606597
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Literature in this Area
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