SEN 12333

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Cat.No. 4441 - SEN 12333 | C20H25N3O2 | CAS No. 874450-44-9
Description: α7 nAChR agonist; histamine H3 antagonist
Alternative Names: WAY 317538
Chemical Name: N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.

Technical Data

M. Wt 339.43
Formula C20H25N3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 874450-44-9
PubChem ID 45484303
InChI Key XCHIZTUBUXZESJ-UHFFFAOYSA-N
Smiles O=C(CCCCN3CCOCC3)NC(C=C2)=CC=C2C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 339.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Roncarati et al (2009) Procognitive and neuroprotective activity of a novel α7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J.Pharmacol.Exp.Ther. 329 459 PMID: 19223665

Beinat et al (2012) Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg.Med.Chem.Lett. 22 2380 PMID: 22410083


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Citations for SEN 12333

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