SEN 12333

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Cat.No. 4441 - SEN 12333 | C20H25N3O2 | CAS No. 874450-44-9
Description: α7 nAChR agonist; also histamine H3 antagonist
Alternative Names: WAY 317538
Chemical Name: N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide
Purity: ≥99% (HPLC)
Literature (6)

Biological Activity

α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.

Technical Data

M. Wt 339.43
Formula C20H25N3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 874450-44-9
PubChem ID 45484303

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 339.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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References are publications that support the biological activity of the product.

Roncarati et al (2009) Procognitive and neuroprotective activity of a novel α7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J.Pharmacol.Exp.Ther. 329 459 PMID: 19223665

Beinat et al (2012) Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg.Med.Chem.Lett. 22 2380 PMID: 22410083

If you know of a relevant reference for SEN 12333, please let us know.

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Literature in this Area

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