Pricing Availability   Qty
Description: Selective prostacyclin IP1 receptor agonist
Alternative Names: NS-304, ACT-293987
Chemical Name: 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide
Purity: ≥98% (HPLC)

Biological Activity for Selexipag

Selexipag is a selective prostacyclin IP1 receptor agonist (Ki values are 260 and 2100 nM and for human and rat IP receptors, and >10 μM for EP1-4, DP, FP, and TP receptors). Prodrug for the active form of MRE 269. Ameliorates vascular endothelial dysfunction and increases femoral skin blood flow in rats. Orally available.

Licensing Information

Sold with the permission of Nippon Shinyaku Co.

Compound Libraries for Selexipag

Selexipag is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Selexipag

M. Wt 496.62
Formula C26H32N4O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 475086-01-2
PubChem ID 9913767
Smiles CC(C)N(CCCCOCC(NS(C)(=O)=O)=O)C1=NC(C3=CC=CC=C3)=C(C2=CC=CC=C2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Selexipag

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.66 100

Preparing Stock Solutions for Selexipag

The following data is based on the product molecular weight 496.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for Selexipag

Certificate of Analysis / Product Datasheet
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