Selexipag

Discontinued Product

Selexipag (Cat. No. 3351) has been withdrawn from sale for commercial reasons.
Description: Selective prostacyclin IP1 receptor agonist
Alternative Names: NS-304,ACT-293987
Chemical Name: 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for Selexipag

Selexipag is a selective prostacyclin IP1 receptor agonist (Ki values are 260 and 2100 nM and for human and rat IP receptors, and >10 μM for EP1-4, DP, FP, and TP receptors). Prodrug for the active form of MRE 269. Ameliorates vascular endothelial dysfunction and increases femoral skin blood flow in rats. Orally available.

Licensing Information

Sold with the permission of Nippon Shinyaku Co.

Compound Libraries for Selexipag

Selexipag is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Selexipag

M. Wt 496.62
Formula C26H32N4O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 475086-01-2
PubChem ID 9913767
InChI Key QXWZQTURMXZVHJ-UHFFFAOYSA-N
Smiles CC(C)N(CCCCOCC(NS(C)(=O)=O)=O)C1=NC(C3=CC=CC=C3)=C(C2=CC=CC=C2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Selexipag

Certificate of Analysis / Product Datasheet
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Citations for Selexipag

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Currently there are no citations for Selexipag.

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