SC 57461A

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Cat.No. 3107 - SC 57461A | C20H25NO3.HCl | CAS No. 423169-68-0
Description: Selective inhibitor of LTA4 hydrolase
Chemical Name: N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Potent and selective inhibitor of LTA4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. Potently inhibits LTB4 production in whole blood (IC50 = 49 nM). Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 363.88
Formula C20H25NO3.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 423169-68-0
PubChem ID 9820433

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 9.1 25
DMSO 36.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 363.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.74 mL 27.48 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Keywords: SC 57461A, SC 57461A supplier, Selective, inhibitors, inhibits, LTA4, hydrolases, SC57461A, Pfizer, Hydrolase, Aminopeptidases, 3107, Tocris Bioscience

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