SC 57461A

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Cat.No. 3107 - SC 57461A | C20H25NO3.HCl | CAS No. 423169-68-0
Description: Selective inhibitor of LTA4 hydrolase
Chemical Name: N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Potent and selective inhibitor of LTA4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. Potently inhibits LTB4 production in whole blood (IC50 = 49 nM). Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 363.88
Formula C20H25NO3.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 423169-68-0
PubChem ID 9820433
InChI Key SBBJJLDNKNNWFJ-UHFFFAOYSA-N
Smiles CN(CCC(O)=O)CCCOC(C=C2)=CC=C2CC1=CC=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.1 25
DMSO 36.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 363.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.74 mL 27.48 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Penning et al (2002) Synthesis of potent leukotriene A4 hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. J.Med.Chem. 45 3482 PMID: 12139459

Askonas et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase I: in vitro studies. J.Pharmacol.Exp.Ther. 300 577 PMID: 11805219

Kachur et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase II: in vivo studies. J.Pharmacol.Exp.Ther. 300 583 PMID: 11805220


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Keywords: SC 57461A, SC 57461A supplier, Selective, inhibitors, inhibits, LTA4, hydrolases, SC57461A, Pfizer, Hydrolase, Aminopeptidases, 3107, Tocris Bioscience

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Literature in this Area

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