SC 51322
Biological Activity
Potent EP1 prostanoid receptor antagonist (Ki = 13.8 nM). Displays analgesic properties in vivo.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 457.93 |
| Formula | C22H20ClN3O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 146032-79-3 |
| PubChem ID | 9933831 |
| InChI Key | CQBVTZDISUKDSX-UHFFFAOYSA-N |
| Smiles | O=C(NNC(CCSCC4=CC=CO4)=O)N3CC1=CC=CC=C1OC2=CC=C(Cl)C=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.79 | 100 | |
| ethanol | 11.45 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 457.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.92 mL | 21.84 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Durocher et al (2000) A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture Anal.Biochem. 284 316 PMID: 10964415
Hallinan et al (1994) 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic. Bioorg.Med.Chem.Lett. 4 509 PMID:
If you know of a relevant reference for SC 51322, please let us know.
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Keywords: SC 51322, supplier, potent, prostanoids, EP1, receptors, antagonists, PGE2, prostaglandins, prostacyclins, eicosanoids, SC51322, Pfizer, Prostanoid, Receptors, Tocris Bioscience
Citations for SC 51322
Citations are publications that use Tocris products.
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