Potent EP1 prostanoid receptor antagonist (Ki = 13.8 nM). Displays analgesic properties in vivo.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 457.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.18 mL||10.92 mL||21.84 mL|
|5 mM||0.44 mL||2.18 mL||4.37 mL|
|10 mM||0.22 mL||1.09 mL||2.18 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the products' biological activity.
Durocher et al (2000) A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture Anal.Biochem. 284 316 PMID: 10964415
Hallinan et al (1994) 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic. Bioorg.Med.Chem.Lett. 4 509 PMID:
If you know of a relevant reference for SC 51322, please let us know.
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Keywords: SC 51322, supplier, potent, prostanoids, EP1, receptors, antagonists, PGE2, prostaglandins, prostacyclins, eicosanoids, SC51322, Pfizer, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.