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SC 51322 is a potent EP1 prostanoid receptor antagonist (Ki = 13.8 nM). Displays analgesic properties in vivo.
Sold for research purposes under agreement from Pfizer Inc.
SC 51322 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 457.93 |
Formula | C22H20ClN3O4S |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 146032-79-3 |
PubChem ID | 9933831 |
InChI Key | CQBVTZDISUKDSX-UHFFFAOYSA-N |
Smiles | O=C(NNC(CCSCC4=CC=CO4)=O)N3CC1=CC=CC=C1OC2=CC=C(Cl)C=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 45.79 | 100 | |
ethanol | 11.45 | 25 |
The following data is based on the product molecular weight 457.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.18 mL | 10.92 mL | 21.84 mL |
5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
References are publications that support the biological activity of the product.
Durocher et al (2000) A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture Anal.Biochem. 284 316 PMID: 10964415
Hallinan et al (1994) 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic. Bioorg.Med.Chem.Lett. 4 509
If you know of a relevant reference for SC 51322, please let us know.
Keywords: SC 51322, SC 51322 supplier, potent, prostanoids, EP1, receptors, antagonists, PGE2, prostaglandins, prostacyclins, eicosanoids, SC51322, Pfizer, Prostanoid, Receptors, 2791, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SC 51322 include:
Guillem-Llobat et al (2016) Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget 7 32462 PMID: 27074574
Do you know of a great paper that uses SC 51322 from Tocris? Please let us know.
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in vivo survival assay
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.