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Description: Potent EP1 receptor antagonist
Chemical Name: 8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid hydrazide
Purity: ≥98% (HPLC)
Biological Activity for SC 51322
SC 51322 is a potent EP1 prostanoid receptor antagonist (Ki = 13.8 nM). Displays analgesic properties in vivo.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for SC 51322
SC 51322 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SC 51322
| M. Wt | 457.93 |
| Formula | C22H20ClN3O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 146032-79-3 |
| PubChem ID | 9933831 |
| InChI Key | CQBVTZDISUKDSX-UHFFFAOYSA-N |
| Smiles | O=C(NNC(CCSCC4=CC=CO4)=O)N3CC1=CC=CC=C1OC2=CC=C(Cl)C=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SC 51322
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.79 | 100 | |
| ethanol | 11.45 | 25 |
Preparing Stock Solutions for SC 51322
The following data is based on the product molecular weight 457.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.92 mL | 21.84 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for SC 51322
References for SC 51322
References are publications that support the biological activity of the product.
Durocher et al (2000) A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture Anal.Biochem. 284 316 PMID: 10964415
Hallinan et al (1994) 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic. Bioorg.Med.Chem.Lett. 4 509
If you know of a relevant reference for SC 51322, please let us know.
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Keywords: SC 51322, SC 51322 supplier, potent, prostanoids, EP1, receptors, antagonists, PGE2, prostaglandins, prostacyclins, eicosanoids, SC51322, Pfizer, Prostanoid, Receptors, 2791, Tocris Bioscience
1 Citation for SC 51322
Citations are publications that use Tocris products. Selected citations for SC 51322 include:
Guillem-Llobat et al (2016) Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget 7 32462 PMID: 27074574
Do you know of a great paper that uses SC 51322 from Tocris? Please let us know.
Reviews for SC 51322
Average Rating: 5 (Based on 1 Review.)
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Anonymous on 05/31/2017
in vivo survival assay
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