SC 51322

Discontinued Product

2791 has been discontinued.

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Description: Potent EP1 receptor antagonist
Chemical Name: 8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid hydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for SC 51322

SC 51322 is a potent EP1 prostanoid receptor antagonist (Ki = 13.8 nM). Displays analgesic properties in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for SC 51322

SC 51322 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SC 51322

M. Wt 457.93
Formula C22H20ClN3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 146032-79-3
PubChem ID 9933831
InChI Key CQBVTZDISUKDSX-UHFFFAOYSA-N
Smiles O=C(NNC(CCSCC4=CC=CO4)=O)N3CC1=CC=CC=C1OC2=CC=C(Cl)C=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SC 51322

References are publications that support the biological activity of the product.

Durocher et al (2000) A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture Anal.Biochem. 284 316 PMID: 10964415

Hallinan et al (1994) 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic. Bioorg.Med.Chem.Lett. 4 509

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Keywords: SC 51322, SC 51322 supplier, potent, prostanoids, EP1, receptors, antagonists, PGE2, prostaglandins, prostacyclins, eicosanoids, SC51322, Pfizer, Prostanoid, Receptors, 2791, Tocris Bioscience

1 Citation for SC 51322

Citations are publications that use Tocris products. Selected citations for SC 51322 include:

Guillem-Llobat et al (2016) Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget 7 32462 PMID: 27074574


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