SC 19220

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Cat.No. 1206 - SC 19220 | C16H14ClN3O3 | CAS No. 19395-87-0
Description: Selective EP1 receptor antagonist
Chemical Name: 8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells).

Compound Libraries

SC 19220 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 331.76
Formula C16H14ClN3O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 19395-87-0
PubChem ID 4336830
InChI Key KNURFLJTOUGOOQ-UHFFFAOYSA-N
Smiles CC(=O)NNC(=O)N1CC2=C(OC3=CC=C(Cl)C=C13)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.18 100
ethanol 8.29 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 331.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Botella et al (1995) Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon. J.Pharmacol.Exp.Ther. 273 1008 PMID: 7791070

Funk et al (1993) Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J.Biol.Chem. 268 26767 PMID: 8253813

Sanner (1972) Dibenzoxazepine hydrazides as prostaglandin antagonists. Intra-Science Chem.Rept. 6 1 PMID:


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Keywords: Selective EP1 receptor antagonist Receptors Prostanoids prostaglandins prostacyclins eicosanoids SC19220 Prostanoid Receptors

1 Citation for SC 19220

Citations are publications that use Tocris products. Selected citations for SC 19220 include:

Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Neuropharmacology 8 138 PMID: 22013477


Do you know of a great paper that uses SC 19220 from Tocris? If so please let us know.

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Pathways for SC 19220

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