SC 19220

Pricing Availability   Qty
Description: Selective EP1 receptor antagonist
Chemical Name: 8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for SC 19220

SC 19220 is a selective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells).

Compound Libraries for SC 19220

SC 19220 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SC 19220

M. Wt 331.76
Formula C16H14ClN3O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 19395-87-0
PubChem ID 4336830
Smiles CC(=O)NNC(=O)N1CC2=C(OC3=CC=C(Cl)C=C13)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SC 19220

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 8.29 25 with gentle warming
DMSO 33.18 100

Preparing Stock Solutions for SC 19220

The following data is based on the product molecular weight 331.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for SC 19220

Certificate of Analysis / Product Datasheet
Select another batch:

References for SC 19220

References are publications that support the biological activity of the product.

Botella et al (1995) Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon. J.Pharmacol.Exp.Ther. 273 1008 PMID: 7791070

Funk et al (1993) Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J.Biol.Chem. 268 26767 PMID: 8253813

Sanner (1972) Dibenzoxazepine hydrazides as prostaglandin antagonists. Intra-Science Chem.Rept. 6 1

If you know of a relevant reference for SC 19220, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Prostanoid Receptor Antagonists

Keywords: SC 19220, SC 19220 supplier, Selective, EP1, receptor, antagonist, Receptors, Prostanoids, prostaglandins, prostacyclins, eicosanoids, SC19220, Prostanoid, 1206, Tocris Bioscience

1 Citation for SC 19220

Citations are publications that use Tocris products. Selected citations for SC 19220 include:

Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Neuropharmacology 8 138 PMID: 22013477

Do you know of a great paper that uses SC 19220 from Tocris? Please let us know.

Reviews for SC 19220

There are currently no reviews for this product. Be the first to review SC 19220 and earn rewards!

Have you used SC 19220?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review