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Urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.
Sold for research purposes under agreement from GlaxoSmithKline.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 491.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.34 mL||101.68 mL||203.36 mL|
|0.5 mM||4.07 mL||20.34 mL||40.67 mL|
|1 mM||2.03 mL||10.17 mL||20.34 mL|
|5 mM||0.41 mL||2.03 mL||4.07 mL|
References are publications that support the biological activity of the product.
Bousette et al (2006) Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Peptides 27 2919 PMID: 16919371
Bousette et al (2006) Urotensin-II blockade with SB-611812 attenutes cardiac dysfunction in a rat model of coronary artery ligation. J.Mol.Cell Cardiol. 41 285 PMID: 16797584
Papadopoulos et al (2008) Urotensin-II and cardiovascular remodeling. Peptides 29 764 PMID: 17988761
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Keywords: SB 611812, SB 611812 supplier, SB611812, GSK, urotensin-II, urotensin, receptors, antagonists, cardiac, dysfunction, remodeling, remodelling, Urotensin-II, Receptors, 4670, Tocris Bioscience
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