Urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.
Sold for research purposes under agreement from GlaxoSmithKline.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 491.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.34 mL||101.68 mL||203.36 mL|
|0.5 mM||4.07 mL||20.34 mL||40.67 mL|
|1 mM||2.03 mL||10.17 mL||20.34 mL|
|5 mM||0.41 mL||2.03 mL||4.07 mL|
References are publications that support the biological activity of the product.
Bousette et al (2006) Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Peptides 27 2919 PMID: 16919371
Bousette et al (2006) Urotensin-II blockade with SB-611812 attenutes cardiac dysfunction in a rat model of coronary artery ligation. J.Mol.Cell Cardiol. 41 285 PMID: 16797584
Papadopoulos et al (2008) Urotensin-II and cardiovascular remodeling. Peptides 29 764 PMID: 17988761
If you know of a relevant reference for SB 611812, please let us know.
View Related Products by Product Action
Keywords: SB 611812, SB 611812 supplier, SB611812, GSK, urotensin-II, urotensin, receptors, antagonists, cardiac, dysfunction, remodeling, remodelling, Urotensin-II, Receptors, 4670, Tocris Bioscience
Citations for SB 611812
Citations are publications that use Tocris products.
Currently there are no citations for SB 611812. Do you know of a great paper that uses SB 611812 from Tocris? Please let us know.
Reviews for SB 611812
There are currently no reviews for this product. Be the first to review SB 611812 and earn rewards!
Have you used SB 611812?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.