SB 611812

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Cat.No. 4670 - SB 611812 | C17H16Cl3F3N2O3S | CAS No. 345892-71-9
Description: Urotensin-II (UT) antagonist; attenuates cardiac dysfunction
Chemical Name: 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity

Urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M. Wt 491.74
Formula C17H16Cl3F3N2O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 345892-71-9
PubChem ID 10278166
Smiles ClC1=CC=C(NS(C2=C(Cl)C=C(C(F)(F)F)C=C2Cl)(=O)=O)C=C1OCCN(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.92 10

Preparing Stock Solutions

The following data is based on the product molecular weight 491.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.34 mL 101.68 mL 203.36 mL
0.5 mM 4.07 mL 20.34 mL 40.67 mL
1 mM 2.03 mL 10.17 mL 20.34 mL
5 mM 0.41 mL 2.03 mL 4.07 mL

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References are publications that support the biological activity of the product.

Bousette et al (2006) Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Peptides 27 2919 PMID: 16919371

Bousette et al (2006) Urotensin-II blockade with SB-611812 attenutes cardiac dysfunction in a rat model of coronary artery ligation. J.Mol.Cell Cardiol. 41 285 PMID: 16797584

Papadopoulos et al (2008) Urotensin-II and cardiovascular remodeling. Peptides 29 764 PMID: 17988761

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Keywords: SB 611812, SB 611812 supplier, SB611812, GSK, urotensin-II, urotensin, receptors, antagonists, cardiac, dysfunction, remodeling, remodelling, Urotensin-II, Receptors, 4670, Tocris Bioscience

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