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Cat.No. 1163 - Saralasin | Sar-Arg-Val-Tyr-Val-His-Pro-Ala | CAS No. 34273-10-4
Description: Non-selective angiotensin II antagonist

Biological Activity

Competitive non-selective angiotensin II antagonist.

Technical Data

M. Wt 912
Formula C42H65N13O10

(Modifications: X = Sar)

Storage Desiccate at -20°C
CAS Number 34273-10-4
PubChem ID 6324663
Smiles [H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 912. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.1 mL 5.48 mL 10.96 mL
5 mM 0.22 mL 1.1 mL 2.19 mL
10 mM 0.11 mL 0.55 mL 1.1 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Steinhausen et al (1986) Angiotensin II control of the renal microcirculation: effect of blockade by saralasin. Kidney Int. 30 56 PMID: 3747343

Thomas et al (1995) Saralasin suppresses arrhythmias in an isolated guinea-pig ventricular free wall model of simulated ischemia and reperfusion. J.Pharmacol.Exp.Ther. 274 1379 PMID: 7562511

If you know of a relevant reference for Saralasin, please let us know.

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