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Submit ReviewSarafotoxin S6c
Description: Selective ETB agonist
Purity: ≥95% (HPLC)
Biological Activity for Sarafotoxin S6c
Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).
Technical Data for Sarafotoxin S6c
| M. Wt | 2516 |
| Formula | C103H147N27O37S5 |
| Sequence |
CTCNDMTDEECLNFCHQDVIW (Modifications: Disulfide bridges: 1-15, 3-11) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 121695-87-2 |
| PubChem ID | 71456935 |
| InChI Key | LXPHPKVWHQLBBA-JHOSIGDNSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Sarafotoxin S6c
References for Sarafotoxin S6c
References are publications that support the biological activity of the product.
Matsuo et al (1997) Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 280 905 PMID: 9023305
Miasiro et al (1998) Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum. J.Cardiovasc.Pharmacol. 31 S175 PMID: 9595431
Williams et al (1991) Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 175 556 PMID: 1850245
Williams et al (1993) Characterization of cloned human endothelin receptors. Life Sci. 53 407 PMID: 8336519
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Keywords: Sarafotoxin S6c, Sarafotoxin S6c supplier, Selective, ETB, agonists, receptors, endothelin, SarafotoxinS6c, venoms, Endothelin, Receptors, 1175, Tocris Bioscience
2 Citations for Sarafotoxin S6c
Citations are publications that use Tocris products. Selected citations for Sarafotoxin S6c include:
Hein et al (2009) Functional and molecular characterization of the endothelin system in retinal arterioles. Br J Pharmacol 50 3329 PMID: 19151386
Ou et al (2014) Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol 229 489 PMID: 24105843
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