Sarafotoxin S6c

Pricing Availability   Qty
Cat.No. 1175 - Sarafotoxin S6c | Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp | CAS No. 121695-87-2
Description: Selective ETB agonist
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Technical Data

M. Wt 2516
Formula C103H147N27O37S5
Sequence CTCNDMTDEECLNFCHQDVIW

(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Storage Desiccate at -20°C
CAS Number 121695-87-2
PubChem ID 71456935
InChI Key LXPHPKVWHQLBBA-JHOSIGDNSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Matsuo et al (1997) Effects of sarafotoxin S6c on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 280 905 PMID: 9023305

Miasiro et al (1998) Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum. J.Cardiovasc.Pharmacol. 31 S175 PMID: 9595431

Williams et al (1991) Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 175 556 PMID: 1850245

Williams et al (1993) Characterization of cloned human endothelin receptors. Life Sci. 53 407 PMID: 8336519


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Keywords: Sarafotoxin S6c, Sarafotoxin S6c supplier, Selective, ETB, agonists, receptors, endothelin, SarafotoxinS6c, venoms, Endothelin, Receptors, 1175, Tocris Bioscience

2 Citations for Sarafotoxin S6c

Citations are publications that use Tocris products. Selected citations for Sarafotoxin S6c include:

Ou et al (2014) Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol 229 489 PMID: 24105843

Hein et al (2009) Functional and molecular characterization of the endothelin system in retinal arterioles. Br J Pharmacol 50 3329 PMID: 19151386


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