Sarafotoxin S6c

Pricing Availability Delivery Time Qty
Cat.No. 1175 - Sarafotoxin S6c | Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp | CAS No. 121695-87-2
Description: Selective ETB agonist
Datasheet
Citations (1)
Literature

Biological Activity

Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Technical Data

M. Wt 2516
Formula C103H147N27O37S5
Sequence CTCNDMTDEECLNFCHQDVIW

(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Storage Desiccate at -20°C
CAS Number 121695-87-2
PubChem ID 71456935
InChI Key LXPHPKVWHQLBBA-JHOSIGDNSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2516. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.4 mL 1.99 mL 3.97 mL
5 mM 0.08 mL 0.4 mL 0.79 mL
10 mM 0.04 mL 0.2 mL 0.4 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Matsuo et al (1997) Effects of sarafotoxin S6c on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 280 905 PMID: 9023305

Miasiro et al (1998) Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum. J.Cardiovasc.Pharmacol. 31 S175 PMID: 9595431

Williams et al (1991) Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 175 556 PMID: 1850245

Williams et al (1993) Characterization of cloned human endothelin receptors. Life Sci. 53 407 PMID: 8336519


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Keywords: Sarafotoxin S6c, supplier, Selective, ETB, agonists, receptors, endothelin, SarafotoxinS6c, venoms, Endothelin, ETB, Receptors, Tocris Bioscience

1 Citation for Sarafotoxin S6c

Citations are publications that use Tocris products. Selected citations for Sarafotoxin S6c include:

Hein et al (2009) Functional and molecular characterization of the endothelin system in retinal arterioles. Br J Pharmacol 50 3329 PMID: 19151386


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Literature in this Area

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Pathways for Sarafotoxin S6c

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