Biological Activity
Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
Technical Data
M. Wt | 975.11 |
Formula | C47H66N12O11 |
Sequence |
XRPPGFSPF (Modifications: X = Sar, Phe-9 = D-Phe) |
Storage | Desiccate at -20°C |
CAS Number | 126959-88-4 |
PubChem ID | 164234 |
InChI Key | YIUBSFCQATYQJB-VCMDLEIESA-N |
Smiles | [H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
Solubility | Soluble to 2 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: 1662280
Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 266 192 PMID: 8392550
Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727
If you know of a relevant reference for Sar-[D-Phe8]-des-Arg9-Bradykinin, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Sar-[D-Phe8]-des-Arg9-Bradykinin, Sar-[D-Phe8]-des-Arg9-Bradykinin supplier, Potent, selective, B1, agonists, Receptors, Bradykinin, 3230, Tocris Bioscience
Citations for Sar-[D-Phe8]-des-Arg9-Bradykinin
Citations are publications that use Tocris products.
Currently there are no citations for Sar-[D-Phe8]-des-Arg9-Bradykinin. Do you know of a great paper that uses Sar-[D-Phe8]-des-Arg9-Bradykinin from Tocris? Please let us know.
Reviews for Sar-[D-Phe8]-des-Arg9-Bradykinin
There are currently no reviews for this product. Be the first to review Sar-[D-Phe8]-des-Arg9-Bradykinin and earn rewards!
Have you used Sar-[D-Phe8]-des-Arg9-Bradykinin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image