Discontinued Product

Sar-[D-Phe8]-des-Arg9-Bradykinin (Cat. No. 3230) has been withdrawn from sale for commercial reasons.
Description: Potent and selective B1 agonist

Biological Activity for Sar-[D-Phe8]-des-Arg9-Bradykinin

Sar-[D-Phe8]-des-Arg9-Bradykinin is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

Technical Data for Sar-[D-Phe8]-des-Arg9-Bradykinin

M. Wt 975.11
Formula C47H66N12O11

(Modifications: X = Sar, Phe-9 = D-Phe)

Storage Desiccate at -20°C
CAS Number 126959-88-4
PubChem ID 164234
Smiles [H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Sar-[D-Phe8]-des-Arg9-Bradykinin

Certificate of Analysis / Product Datasheet
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References for Sar-[D-Phe8]-des-Arg9-Bradykinin

References are publications that support the biological activity of the product.

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: 1662280

Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 266 192 PMID: 8392550

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727

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Keywords: Sar-[D-Phe8]-des-Arg9-Bradykinin, Sar-[D-Phe8]-des-Arg9-Bradykinin supplier, Potent, selective, B1, agonists, Receptors, Bradykinin, 3230, Tocris Bioscience

Citations for Sar-[D-Phe8]-des-Arg9-Bradykinin

Citations are publications that use Tocris products.

Currently there are no citations for Sar-[D-Phe8]-des-Arg9-Bradykinin.

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