Sar-[D-Phe8]-des-Arg9-Bradykinin

Discontinued Product

Sar-[D-Phe8]-des-Arg9-Bradykinin (Cat. No. 3230) has been withdrawn from sale for commercial reasons.
Description: Potent and selective B1 agonist
Datasheet
Citations
Reviews

Biological Activity for Sar-[D-Phe8]-des-Arg9-Bradykinin

Sar-[D-Phe8]-des-Arg9-Bradykinin is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

Technical Data for Sar-[D-Phe8]-des-Arg9-Bradykinin

M. Wt 975.11
Formula C47H66N12O11
Sequence XRPPGFSPF

(Modifications: X = Sar, Phe-9 = D-Phe)

Storage Desiccate at -20°C
CAS Number 126959-88-4
PubChem ID 164234
InChI Key YIUBSFCQATYQJB-VCMDLEIESA-N
Smiles [H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Sar-[D-Phe8]-des-Arg9-Bradykinin

Certificate of Analysis / Product Datasheet
Select another batch:

References for Sar-[D-Phe8]-des-Arg9-Bradykinin

References are publications that support the biological activity of the product.

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: 1662280

Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 266 192 PMID: 8392550

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727

View Related Products by Product Action

View all Bradykinin Receptor Agonists

Keywords: Sar-[D-Phe8]-des-Arg9-Bradykinin, Sar-[D-Phe8]-des-Arg9-Bradykinin supplier, Potent, selective, B1, agonists, Receptors, Bradykinin, 3230, Tocris Bioscience

Citations for Sar-[D-Phe8]-des-Arg9-Bradykinin

Citations are publications that use Tocris products.

Currently there are no citations for Sar-[D-Phe8]-des-Arg9-Bradykinin.

Reviews for Sar-[D-Phe8]-des-Arg9-Bradykinin

There are currently no reviews for this product. Be the first to review Sar-[D-Phe8]-des-Arg9-Bradykinin and earn rewards!

Have you used Sar-[D-Phe8]-des-Arg9-Bradykinin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review