Sar-[D-Phe8]-des-Arg9-Bradykinin

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Cat.No. 3230 - Sar-[D-Phe8]-des-Arg9-Bradykinin | Sar-Arg-Pro-Pro-Gly-Phe-Ser-Pro-D-Phe | CAS No. 126959-88-4
Description: Potent and selective B1 agonist
Datasheet
Citations
Literature

Biological Activity

Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

Technical Data

M. Wt 975.11
Formula C47H66N12O11
Sequence XRPPGFSPF

(Modifications: X = Sar, Phe-9 = D-Phe)

Storage Desiccate at -20°C
CAS Number 126959-88-4
PubChem ID 164234
InChI Key YIUBSFCQATYQJB-VCMDLEIESA-N
Smiles [H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 975.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.13 mL 10.26 mL
5 mM 0.21 mL 1.03 mL 2.05 mL
10 mM 0.1 mL 0.51 mL 1.03 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: 1662280

Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 266 192 PMID: 8392550

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727


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Keywords: Potent selective B1 agonists Receptors Bradykinin Bradykinin Receptors

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