Salermide

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Cat.No. 4127 - Salermide | C26H22N2O2 | CAS No. 1105698-15-4
Description: SIRT1 and SIRT2 inhibitor
Chemical Name: N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.

Technical Data

M. Wt 394.47
Formula C26H22N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1105698-15-4
PubChem ID 53393948
InChI Key UADRPWLRVLBVBC-UHFFFAOYSA-N
Smiles O=C(C(C)C4=CC=CC=C4)NC1=CC=CC(/N=C/C3=C(O)C=CC2=CC=CC=C23)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 394.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789 PMID: 16302818

Lara et al (2009) Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene 28 781 PMID: 19060927

Pasco et al (2010) Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. J.Med.Chem. 53 1407 PMID: 20041717


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Keywords: Salermide, Salermide supplier, sirt1, sirt2, sirtuin, sir2-like, inhibitors, inhibits, apoptosis, proapoptotic, antitumor, agents, Class, III, HDACs, (Sirtuins), 4127, Tocris Bioscience

Citations for Salermide

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Literature in this Area

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