SAHM1

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Cat.No. 6477 - SAHM1 | Ac-β-Ala-Glu-Arg-Leu-Arg-Arg-Arg-Ile-[(S)-2-(4-pentenyl)alanine]-Leu-Cys-Arg-[(S)-2-(4-pentenyl)alanine]-His-His-Ser-Thr (double bond covalent bridge: X-9-X-13) | CAS No. 2050906-89-1
Description: Notch pathway inhibitor; prevents Notch complex assembly
Datasheet
Citations
Reviews
Literature

Biological Activity

Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Technical Data

M. Wt 2196.58
Formula C94H162N36O23S
Sequence AERLRRRIXLCRXHHST

(Modifications: Ala-1 = N-terminal Ac, Ala-1 = β-Ala, X = (S)-2-(4-pentenyl)alanine, X-9 and X-13 stapled together with a double bond)

Storage Store at -20°C
CAS Number 2050906-89-1
InChI Key ADWKVIAAKDSBNE-WDPRGXETNA-N
Smiles [H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ashley et al (2015) Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem 116 2598 PMID: 25914241

Bagheri et al (2018) Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J.Tissue Eng.Regen.Med. 12 304 PMID: 28482141

KleinJan et al (2018) The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J.Allergy Clin.Immunol. 142 76 PMID: 29111218


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Keywords: SAHM1, SAHM1 supplier, Notch, pathway, inhibitors, inhibits, MAML1, complex, assembly, stapled, peptide, Other, Signaling, 6477, Tocris Bioscience

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