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Description: Notch pathway inhibitor; prevents Notch complex assembly
Purity: ≥95% (HPLC)

Biological Activity for SAHM1

SAHM1 is a notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Technical Data for SAHM1

M. Wt 2196.58
Formula C94H162N36O23S

(Modifications: Ala-1 = N-terminal Ac & β-Ala, X = (S)-2-(4-pentenyl)alanine, X-9 and X-13 stapled together with a double bond)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2050906-89-1
PubChem ID 137919859
Smiles [H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SAHM1

Solubility Soluble to 1 mg/ml in water

Product Datasheets for SAHM1

Certificate of Analysis / Product Datasheet
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References for SAHM1

References are publications that support the biological activity of the product.

Ashley et al (2015) Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem 116 2598 PMID: 25914241

Bagheri et al (2018) Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J.Tissue Eng.Regen.Med. 12 304 PMID: 28482141

KleinJan et al (2018) The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J.Allergy Clin.Immunol. 142 76 PMID: 29111218

If you know of a relevant reference for SAHM1, please let us know.

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Keywords: SAHM1, SAHM1 supplier, Notch, pathway, inhibitors, inhibits, MAML1, complex, assembly, stapled, peptide, Other, Signaling, Stapled, Peptides, 6477, Tocris Bioscience

Citations for SAHM1

Citations are publications that use Tocris products.

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