S26948

Pricing Availability Delivery Time Qty
Cat.No. 3690 - S26948 | C28H25NO7S | CAS No. 353280-43-0
Description: Selective PPARγ agonist; antidiabetic agent
Chemical Name: [[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioic acid dimethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective PPARγ agonist (EC50 = 8.83 nM). Drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice. Displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats.

Compound Libraries

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Technical Data

M. Wt 519.57
Formula C28H25NO7S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 353280-43-0
PubChem ID 9958279
InChI Key NSMJEHGOMXSLCW-UHFFFAOYSA-N
Smiles O=C(C3=CC=CC=C3)C1=CC=C(N(CCOC4=CC=C(CC(C(OC)=O)C(OC)=O)C=C4)C(S2)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 519.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL
10 mM 0.19 mL 0.96 mL 1.92 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Carmona et al (2007) S 26948: a new specific peroxisome proliferator-activated receptor γ modulator with potent antidiabetes and antiatherogenic effects. Diabetes 56 2797 PMID: 17704298

Sohn et al (2009) S26948, a new specific peroxisome proliferator activated receptor gamma modulator improved in vivo hepatic insulin sensitivity in 48 h lipid infused rats. Eur.J.Pharmacol. 608 104 PMID: 19250932


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Keywords: Peroxisome Proliferator-activating Receptors PPARg PPARγ PPARgamma agonists antidiabetic S26948 PPARgamma Receptors

Citations for S26948

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Literature in this Area

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Pathways for S26948

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