Discontinued ProductUnfortunately (S)-Methyl-L-thiocitrulline dihydrochloride (Cat. No. 0733) has been withdrawn from sale for commercial reasons.
NO synthase inhibitor (IC50 values are 1.05 and 2.2 μM for rat nNOS and iNOS respectively). Has strong pressor activity in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 278.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.59 mL||17.97 mL||35.95 mL|
|5 mM||0.72 mL||3.59 mL||7.19 mL|
|10 mM||0.36 mL||1.8 mL||3.59 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
References are publications that support the products' biological activity.
Joly et al (1995) Characterization of the effects of two new arginine/citrulline analogues on constitutive and inducible nitric oxide synthases in rat aorta. Br.J.Pharmacol. 115 491 PMID: 7582462
Narayanan et al (1995) S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo. J.Biol.Chem. 270 11103 PMID: 7538112
Narayanan and Griffith (1994) Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L-thiocitrulline: a new class of potent nitric oxide synthase inhibitors. J.Med.Chem. 37 885 PMID: 7512141
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Keywords: (S)-Methyl-L-thiocitrulline dihydrochloride, supplier, Non-selective, NOS, Non-selective, NOS, Tocris Bioscience
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