(S)-Equol

Discontinued Product

(S)-Equol (Cat. No. 6158) has been withdrawn from sale for commercial reasons.
Cat.No. 6158 - (S)-Equol | C15H14O3 | CAS No. 531-95-3
Description: Potent estrogen receptor β (ERβ) agonist; dihydrotestosterone antagonist
Chemical Name: (3S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity for (S)-Equol

(S)-Equol is a potent estrogen receptor β (ERβ) agonist (EC50 = 65 nM). Exhibits 13-fold selectivity for ERβ over ERα. Atheroprotective. Protects against t-BHP induced apoptosis and attenuates ER stress in HUVECs. Activates Nrf2 signaling in vitro and in vivo. Inhibits tumor growth. Also dihydrotestosterone antagonist in vivo.

Technical Data for (S)-Equol

M. Wt 242.27
Formula C15H14O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 531-95-3
PubChem ID 91469
InChI Key ADFCQWZHKCXPAJ-GFCCVEGCSA-N
Smiles OC1=CC=C([C@H]2COC3=CC(O)=CC=C3C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: (S)-Equol, (S)-Equol supplier, agonist, estrogen, receptor, beta, ERb, ERbeta, ERβ, Nrf2, Estrogen, and, Related, Receptors, Androgen, Receptor, 6158, Tocris Bioscience

Citations for (S)-Equol

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Literature in this Area

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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  • Invasion and Metastasis
Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for (S)-Equol

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.