Discontinued Product

(S)-Equol (Cat. No. 6158) has been withdrawn from sale for commercial reasons.
Description: Potent estrogen receptor β (ERβ) agonist; dihydrotestosterone antagonist
Chemical Name: (3S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for (S)-Equol

(S)-Equol is a potent estrogen receptor β (ERβ) agonist (EC50 = 65 nM). Exhibits 13-fold selectivity for ERβ over ERα. Atheroprotective. Protects against t-BHP induced apoptosis and attenuates ER stress in HUVECs. Activates Nrf2 signaling in vitro and in vivo. Inhibits tumor growth. Also dihydrotestosterone antagonist in vivo.

Technical Data for (S)-Equol

M. Wt 242.27
Formula C15H14O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 531-95-3
PubChem ID 91469
Smiles OC1=CC=C([C@H]2COC3=CC(O)=CC=C3C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: (S)-Equol, (S)-Equol supplier, agonist, estrogen, receptor, beta, ERb, ERbeta, ERβ, Nrf2, Estrogen, and, Related, Receptors, Androgen, Receptor, 6158, Tocris Bioscience

Citations for (S)-Equol

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Pathways for (S)-Equol

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.