(S)-C33

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Cat.No. 6035 - (S)-C33 | C18H20ClN5O | CAS No. 2066488-39-7
Description: Potent PDE9 inhibitor
Chemical Name: 6-[[(1S)-1-(4-Chlorophenyl)ethyl]amino]-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent PDE9 inhibitor (IC50 = 11 nM).

Technical Data

M. Wt 357.84
Formula C18H20ClN5O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2066488-39-7
PubChem ID 91885385
InChI Key CRRDKKMBUNVLKQ-NSHDSACASA-N
Smiles C[C@@H](C1=CC=C(C=C1)Cl)NC2=NC(C3=C(N(C4CCCC4)N=C3)N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.78 100
ethanol 35.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 357.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.97 mL 27.95 mL
5 mM 0.56 mL 2.79 mL 5.59 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Huang et al (2015) Structural asymmetry of phosphodiesterase-9A and a unique pocket for selective binding of a potent enantiomeric inhibitor. Mol.Pharmacol. 88 836 PMID: 26316540


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Keywords: (S)-C33, supplier, phosphodiesterase, PDE9, inhibitor, Potent, SC33, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

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