Active enantiomer of AMPA (EC50 = 3.5 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 186.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.37 mL||26.86 mL||53.71 mL|
|5 mM||1.07 mL||5.37 mL||10.74 mL|
|10 mM||0.54 mL||2.69 mL||5.37 mL|
|50 mM||0.11 mL||0.54 mL||1.07 mL|
References are publications that support the products' biological activity.
Falch et al (1998) Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. J.Med.Chem. 41 2513 PMID: 9651156
Hansen et al (1983) Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. J.Med.Chem. 26 901 PMID: 6133955
Lauridsen et al (1985) Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors. J.Med.Chem. 28 668 PMID: 2859375
If you know of a relevant reference for (S)-AMPA, please let us know.
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Keywords: (S)-AMPA, supplier, Selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
8 Citations for (S)-AMPA
Citations are publications that use Tocris products. Selected citations for (S)-AMPA include:
Langner et al (2017) Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms. Neurochem Res 42 838 PMID: 27444613
Jackson et al (2010) Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS One 5 e11962 PMID: 20694145
Park et al (2016) Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation. Invest Ophthalmol Vis Sci 57 508 PMID: 26868754
Bell et al (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. PLoS One 6 7066 PMID: 25967870
Pooler et al (2013) Physiological release of endogenous tau is stimulated by neuronal activity. J Neurosci 14 389 PMID: 23412472
Oh et al (2012) Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells. EMBO Rep 7 e47846 PMID: 23110111
Lussier et al (2011) Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. Proc Natl Acad Sci U S A 31 3077 PMID: 21414928
Limon et al (2007) Properties of GluR3 receptors tagged with GFP at the amino or carboxyl terminus. Neuroreport 104 15526 PMID: 17881566
Do you know of a great paper that uses (S)-AMPA from Tocris? If so please let us know.
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