(S)-(-)-5-Iodowillardiine

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Cat.No. 0307 - (S)-(-)-5-Iodowillardiine | C7H8IN3O4 | CAS No. 140187-25-3
Description: Highly potent, subtype-selective kainate agonist
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Demonstrates high affinity for the kainate receptor subtype hGluR5 (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6.

Technical Data

M. Wt 325.06
Formula C7H8IN3O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 140187-25-3
PubChem ID 447196
InChI Key AXXYLTBQIQBTES-BYPYZUCNSA-N
Smiles O=C(N1)N(C[C@]([H])(N)C(O)=O)C=C(I)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 8.12 25

Preparing Stock Solutions

The following data is based on the product molecular weight 325.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.38 mL 30.76 mL
5 mM 0.62 mL 3.08 mL 6.15 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jane et al (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 40 3645 PMID: 9357531

Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12 595 PMID: 1371315

Swanson et al (1998) Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol.Pharmacol. 53 942 PMID: 9584222

Wong et al (1994) Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 14 3881 PMID: 7515954

Thompson et al (1996) Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots. Br.J.Pharmacol. 117 331P PMID:


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Keywords: potent subtype selective kainate agonists Glutamate Kainate Receptors iGluR Ionotropic Kainate Receptors

1 Citation for (S)-(-)-5-Iodowillardiine

Citations are publications that use Tocris products. Selected citations for (S)-(-)-5-Iodowillardiine include:

Pansiot et al (2010) Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat. Proc Natl Acad Sci U S A 5 e10916 PMID: 20532231


Do you know of a great paper that uses (S)-(-)-5-Iodowillardiine from Tocris? If so please let us know.

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