S 2101

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Cat.No. 5714 - S 2101 | C16H15F2NO.HCl | CAS No. 1239262-36-2
Description: LSD1 inhibitor
Chemical Name: (1R,2S)-rel-2-[3,5-Difluoro-2-(phenylmethoxy)phenyl]cycloprpanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

LSD1 inhibitor (IC50 = 990 nM; Ki = 610 nM). Exhibits selectivity for LSD1 over MAO-B and MAO-A (Ki values are 17 and 110 μM, respectively).

Technical Data

M. Wt 311.75
Formula C16H15F2NO.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1239262-36-2
PubChem ID 121513887
InChI Key CTSUZAFTJVLOIX-SBKWZQTDSA-N
Smiles FC1=CC([C@@H]2C[C@H]2N)=C(OCC3=CC=CC=C3)C(F)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.18 100
water 15.59 50

Preparing Stock Solutions

The following data is based on the product molecular weight 311.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.04 mL 32.08 mL
5 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.32 mL 1.6 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References

References are publications that support the biological activity of the product.

Mimasu et al (2010) Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1. Biochemistry 49 6494 PMID: 20568732


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Keywords: S 2101, S 2101 supplier, S2101, LSD1, inhibitors, inhibits, histones, demethylases, KDM1, Histone, Demethylases, 5714, Tocris Bioscience

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