Potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 493.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.03 mL||10.13 mL||20.26 mL|
|5 mM||0.41 mL||2.03 mL||4.05 mL|
|10 mM||0.2 mL||1.01 mL||2.03 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
References are publications that support the products' biological activity.
Bianchi (1997) Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle. Biochem.Pharmacol. 53 909 PMID: 9174102
Sutko et al (1985) Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Fed.Proc. 44 2984 PMID: 2415406
Sutko et al (1997) The pharmacology of ryanodine and related compounds. Pharmacol.Rev. 49 53 PMID: 9085309
If you know of a relevant reference for Ryanodine, please let us know.
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Keywords: Ryanodine, supplier, Ca2+, release, inhibitors, inhibits, Calcium, Signaling, Signalling, Agents, General, General, Calcium, Signaling, Agents, Ryanodine, Receptors, Ryanodine, Receptors, Tocris Bioscience
20 Citations for Ryanodine
Citations are publications that use Tocris products. Selected citations for Ryanodine include:
Nordman and Kabbani (2014) Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. J Neurosci 28 2995 PMID: 24687992
Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Am J Physiol Cell Physiol 8 e66404 PMID: 23799098
Kyle et al (2013) Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists. Korean J Physiol Pharmacol 305 C609 PMID: 23804200
Lotteau et al (2013) Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle. PLoS One 8 e58673 PMID: 23536811
Zhou et al (2012) Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J Appl Physiol (1985) 112 627 PMID: 22114176
Few et al (2012) Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A 109 E452 PMID: 22308469
Begum et al (2012) DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. J Neurochem 120 622 PMID: 22129278
Low et al (2012) Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner. PLoS One 7 e46999 PMID: 23056554
Fernández-Velasco et al (2011) RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS One 6 e20863 PMID: 21673970
Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545 PMID: 21844187
Kim et al (2011) Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells. PLoS One 15 431 PMID: 22359482
Xu et al (2011) The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains. PLoS One 31 17074 PMID: 22114277
Karwatsky et al (2010) Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling. J Lipid Res 51 1144 PMID: 19965585
Kim et al (2010) Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation. Int J Clin Exp Pathol 19 783 PMID: 20001453
Gerich et al (2009) H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. FASEB J 458 937 PMID: 19430810
Dror et al (2008) Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. J Biol Chem 283 9909 PMID: 18174159
Larina and Thorn (2005) Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses. J Cell Sci 118 4131 PMID: 16118245
Li (2017) Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease. Proc Natl Acad Sci U.S.A. 114 5527 PMID: 28484012
Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. J Neurosci Res 10 e0125974 PMID: 25933382
Zhang et al (2015) Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel. Pflugers Arch 8 10239 PMID: 26617732
Do you know of a great paper that uses Ryanodine from Tocris? If so please let us know.