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Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 339.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||3.93 mL||19.65 mL||39.3 mL|
|3.75 mM||0.79 mL||3.93 mL||7.86 mL|
|7.5 mM||0.39 mL||1.96 mL||3.93 mL|
|37.5 mM||0.08 mL||0.39 mL||0.79 mL|
References are publications that support the biological activity of the product.
Goodman et al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457 PMID: 7949100
Heil et al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987 PMID: 14579267
Lee et al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646 PMID: 12738885
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Keywords: RWJ 21757, RWJ 21757 supplier, Toll-like, receptors, 7, TLR7, agonists, RWJ21757, Loxoribine, 7-Allyl-8-oxoguanosine, Receptors, Antivirals, 2719, Tocris Bioscience
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Literature in this Area
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