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Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
|Storage||Desiccate at +4°C|
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Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Goodman et al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457 PMID: 7949100
Heil et al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987 PMID: 14579267
Lee et al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646 PMID: 12738885
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Keywords: RWJ 21757, RWJ 21757 supplier, Toll-like, receptors, 7, TLR7, agonists, RWJ21757, Loxoribine, 7-Allyl-8-oxoguanosine, Receptors, Antivirals, 2719, Tocris Bioscience
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