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Submit ReviewRWJ 21757
Discontinued Product
RWJ 21757 (Cat. No. 2719) has been withdrawn from sale for commercial reasons.
Description: Toll-like receptor 7 (TLR7) agonist
Alternative Names: Loxoribine, 7-Allyl-8-oxoguanosine
Chemical Name: 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine
Purity: ≥97% (HPLC)
Biological Activity for RWJ 21757
Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
Technical Data for RWJ 21757
| M. Wt | 339.3 |
| Formula | C13H17N5O6 |
| Storage | Desiccate at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 121288-39-9 |
| PubChem ID | 60737 |
| InChI Key | VDCRFBBZFHHYGT-IOSLPCCCSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N(C(N3CC=C)=O)C2=C3C(NC(N)=N2)=O)[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RWJ 21757
References for RWJ 21757
References are publications that support the biological activity of the product.
Goodman et al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457 PMID: 7949100
Heil et al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987 PMID: 14579267
Lee et al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646 PMID: 12738885
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Keywords: RWJ 21757, RWJ 21757 supplier, Toll-like, receptors, 7, TLR7, agonists, RWJ21757, Loxoribine, 7-Allyl-8-oxoguanosine, Receptors, 2719, Tocris Bioscience
Citations for RWJ 21757
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Currently there are no citations for RWJ 21757.
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Pathways for RWJ 21757
