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RWJ 21757

Cat. No. 2719 Submit a Review Datasheet / COA / SDS

Discontinued Product

2719 has been discontinued.

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Description: Toll-like receptor 7 (TLR7) agonist
Alternative Names: Loxoribine,7-Allyl-8-oxoguanosine
Chemical Name: 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for RWJ 21757

Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.

Technical Data for RWJ 21757

M. Wt 339.3
Formula C13H17N5O6
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 121288-39-9
PubChem ID 60737
InChI Key VDCRFBBZFHHYGT-IOSLPCCCSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C(N3CC=C)=O)C2=C3C(NC(N)=N2)=O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RWJ 21757

Certificate of Analysis / Product Datasheet
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References for RWJ 21757

References are publications that support the biological activity of the product.

Goodman et al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457 PMID: 7949100

Heil et al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987 PMID: 14579267

Lee et al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646 PMID: 12738885

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Keywords: RWJ 21757, RWJ 21757 supplier, Toll-like, receptors, 7, TLR7, agonists, RWJ21757, Loxoribine, 7-Allyl-8-oxoguanosine, Receptors, 2719, Tocris Bioscience

Citations for RWJ 21757

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Pathways for RWJ 21757

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.