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RU 58668

Cat. No. 3224 2 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

This product has been withdrawn from sale and is superseded by Endoxifen (Cat. No. 3705)
Description: Pure antiestrogen
Chemical Name: (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]pentyl]oxy]phenylestra-1,3,5,(10)-triene-3,17-diol
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for RU 58668

Pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.

Technical Data for RU 58668

M. Wt 658.76
Formula C34H43F5O5S
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 151555-47-4
PubChem ID 6918261
InChI Key SDCUWFRXMLQNCS-LFAPAAFUSA-N
Smiles OC1=CC=C2C(CC[C@]3([H])[C@@]([H])2[C@@H]([C@]5=CC=C(OCCCCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)C=C5)C[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for RU 58668

References are publications that support the biological activity of the product.

Muller et al (1998) Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. Cancer Res. 58 263 PMID: 9443403

Van de Velde et al (1996) RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity. J.Steroid Molec.Biol. 59 449

Ameller et al (2004) Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in OE-dependent cancers. J.Steroid Molec.Biol. 92 1

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Keywords: RU 58668, RU 58668 supplier, RU58668, pure, antiestrogen, antioestrogen, estrogen, receptors, ER, Estrogen, and, Related, Receptors, 3224, Tocris Bioscience

2 Citations for RU 58668

Citations are publications that use Tocris products. Selected citations for RU 58668 include:

Toy et al (2017) Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists. Cancer Discov 7 277 PMID: 27986707

Adurthi et al (2017) Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. Sci Rep 7 17289 PMID: 29229929

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Pathways for RU 58668

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.