Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRU 58668
Description: Pure antiestrogen
Chemical Name: (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]pentyl]oxy]phenylestra-1,3,5,(10)-triene-3,17-diol
Purity: ≥95% (HPLC)
Biological Activity for RU 58668
Pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.
Technical Data for RU 58668
| M. Wt | 658.76 |
| Formula | C34H43F5O5S |
| Storage | Store at +4°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 151555-47-4 |
| PubChem ID | 6918261 |
| InChI Key | SDCUWFRXMLQNCS-LFAPAAFUSA-N |
| Smiles | OC1=CC=C2C(CC[C@]3([H])[C@@]([H])2[C@@H]([C@]5=CC=C(OCCCCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)C=C5)C[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RU 58668
References for RU 58668
References are publications that support the biological activity of the product.
Muller et al (1998) Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. Cancer Res. 58 263 PMID: 9443403
Van de Velde et al (1996) RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity. J.Steroid Molec.Biol. 59 449
Ameller et al (2004) Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in OE-dependent cancers. J.Steroid Molec.Biol. 92 1
View Related Products by Target
Keywords: RU 58668, RU 58668 supplier, RU58668, pure, antiestrogen, antioestrogen, estrogen, receptors, ER, Estrogen, and, Related, Receptors, 3224, Tocris Bioscience
2 Citations for RU 58668
Citations are publications that use Tocris products. Selected citations for RU 58668 include:
Toy et al (2017) Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists. Cancer Discov 7 277 PMID: 27986707
Adurthi et al (2017) Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. Sci Rep 7 17289 PMID: 29229929
Reviews for RU 58668
There are currently no reviews for this product. Be the first to review RU 58668 and earn rewards!
Have you used RU 58668?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Pathways for RU 58668
