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Cat.No. 3705 - Endoxifen | C25H27NO2 | CAS No. 110025-28-0
Description: Potent antiestrogen; ERα ligand
Chemical Name: (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
Purity: ≥98% (HPLC)
Literature (2)
Pathways (1)

Biological Activity for Endoxifen

Endoxifen is an estrogen receptor α (ERα) ligand; potent antiestrogen. Metabolite of tamoxifen (Cat. No. 0999). Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.

Technical Data for Endoxifen

M. Wt 373.49
Formula C25H27NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 110025-28-0
PubChem ID 130621
Smiles CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=C(O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Endoxifen

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.35 100

Preparing Stock Solutions for Endoxifen

The following data is based on the product molecular weight 373.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.39 mL 26.77 mL
5 mM 0.54 mL 2.68 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for Endoxifen

Certificate of Analysis / Product Datasheet
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References for Endoxifen

References are publications that support the biological activity of the product.

Lim et al (2006) Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J.Pharmacol.Exp.Ther. 318 503 PMID: 16690721

Wu et al (2009) The tamox. metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor a for degradation in breast cancer cells. Cancer Res. 69 1722 PMID: 19244106

Wu et al (2011) Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 13 R27 PMID: 21392396

If you know of a relevant reference for Endoxifen, please let us know.

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Citations for Endoxifen

Citations are publications that use Tocris products.

Currently there are no citations for Endoxifen. Do you know of a great paper that uses Endoxifen from Tocris? Please let us know.

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Literature in this Area

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Pathways for Endoxifen


Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.