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Submit ReviewRU 28318, potassium salt
Description: Potent, selective mineralocorticoid receptor antagonist
Alternative Names: Oxprenoate potassium
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt
Purity: ≥98% (HPLC)
Biological Activity for RU 28318, potassium salt
RU 28318, potassium salt is a potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.
Technical Data for RU 28318, potassium salt
| M. Wt | 440.66 |
| Formula | C25H37O4K |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 76676-34-1 |
| PubChem ID | 23677972 |
| InChI Key | HXJITUGMCJCKCE-UYOQDFFISA-M |
| Smiles | [K+].[H][C@@]12CC[C@@](O)(CCC([O-])=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@H](CCC)CC2=CC(=O)CC[C@]12C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RU 28318, potassium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.07 | 100 |
Preparing Stock Solutions for RU 28318, potassium salt
The following data is based on the product molecular weight 440.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.35 mL | 22.69 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets for RU 28318, potassium salt
References for RU 28318, potassium salt
References are publications that support the biological activity of the product.
Kim et al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213 PMID: 9879980
Perroteau et al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853 PMID: 6323881
Rahmouni et al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199 PMID: 10607876
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Keywords: RU 28318, potassium salt, RU 28318, potassium salt supplier, Potent, selective, mineralocorticoid, antagonists, Aldosterone, Receptors, RU28318, potassium, salt, Oxprenoate, Mineralocorticoid, Receptor, 1672, Tocris Bioscience
6 Citations for RU 28318, potassium salt
Citations are publications that use Tocris products. Selected citations for RU 28318, potassium salt include:
Dorey et al (2012) Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology 37 2870 PMID: 22948976
Sabourin et al (2016) Transient receptor potential canonical (TRPC)/Orai1-dependent store-operated Ca2+ channels: New targets of aldosterone in cardiomyocytes. J.Biol.Chem. 291 13394 PMID: 27129253
Luther et al (2011) Aldosterone decreases glucose-stimulated Ins secretion in vivo in mice and in murine islets. Diabetologia 54 2152 PMID: 21519965
Crochemore et al (2005) Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. J Neurosci 10 790 PMID: 15940303
Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. Proc Natl Acad Sci U S A 25 4288 PMID: 15858055
Mayanagi et al (2008) Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem 283 31183 PMID: 18772142
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