RU 28318, potassium salt

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Cat.No. 1672 - RU 28318, potassium salt | C25H37O4K | CAS No. 76676-34-1
Description: Potent, selective mineralocorticoid receptor antagonist
Alternative Names: Oxprenoate potassium
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.

Technical Data

M. Wt 440.66
Formula C25H37O4K
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 76676-34-1
PubChem ID 23677972
InChI Key HXJITUGMCJCKCE-UYOQDFFISA-M
Smiles [K+].[H][C@@]12CC[C@@](O)(CCC([O-])=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@H](CCC)CC2=CC(=O)CC[C@]12C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.41 10
ethanol 44.07 100
water 44.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 440.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.69 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213 PMID: 9879980

Perroteau et al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853 PMID: 6323881

Rahmouni et al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199 PMID: 10607876


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Keywords: Potent selective mineralocorticoid antagonists Aldosterone Receptors RU28318 potassium salt Oxprenoate potassium Mineralocorticoid Receptor

6 Citations for RU 28318, potassium salt

Citations are publications that use Tocris products. Selected citations for RU 28318, potassium salt include:

Luther et al (2011) Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia 54 2152 PMID: 21519965

Mayanagi et al (2008) Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem 283 31183 PMID: 18772142

Crochemore et al (2005) Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. J Neurosci 10 790 PMID: 15940303

Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. Proc Natl Acad Sci U S A 25 4288 PMID: 15858055

Sabourin et al (2016) Transient receptor potential canonical (TRPC)/Orai1-dependent store-operated Ca2+ channels: New targets of aldosterone in cardiomyocytes. J.Biol.Chem. 291 13394 PMID: 27129253

Dorey et al (2012) Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology 37 2870 PMID: 22948976


Do you know of a great paper that uses RU 28318, potassium salt from Tocris? If so please let us know.

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