RU 26752
Biological Activity
Mineralocorticoid receptor antagonist. Prevents aldosterone-induced hypertension in rats.
Technical Data
| M. Wt | 384.55 |
| Formula | C25H36O3 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 76676-33-0 |
| PubChem ID | 9886385 |
| InChI Key | MOFIIHQCTIJVBB-JEHIOXJOSA-N |
| Smiles | O=C1CC[C@@]2(C)C(C[C@@H](CCC)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.61 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 384.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.6 mL | 13 mL | 26 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Kalimi et al (1990) Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats. Am.J.Physiol. 258 E737 PMID: 2333987
Huyet et al (2007) Structural basis of spirolactone recognition by the mineralocorticoid receptor. Mol.Pharmacol. 72 563 PMID: 17569793
Lazar and Agarwal (1986) Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists. Biochem.Biophy.Res.Comms. 134 261 PMID:
If you know of a relevant reference for RU 26752, please let us know.
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Keywords: Mineralocorticoid receptors antagonists Aldosterone RU26752 Mineralocorticoid Receptor
Citations for RU 26752
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