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Submit ReviewRU 26752
Discontinued Product
RU 26752 (Cat. No. 2970) has been withdrawn from sale for commercial reasons.
Description: Mineralocorticoid receptor antagonist
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid γ-lactone
Purity: ≥99% (HPLC)
Biological Activity
Mineralocorticoid receptor antagonist. Prevents aldosterone-induced hypertension in rats.
Technical Data
| M. Wt | 384.55 |
| Formula | C25H36O3 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 76676-33-0 |
| PubChem ID | 9886385 |
| InChI Key | MOFIIHQCTIJVBB-JEHIOXJOSA-N |
| Smiles | O=C1CC[C@@]2(C)C(C[C@@H](CCC)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Kalimi et al (1990) Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats. Am.J.Physiol. 258 E737 PMID: 2333987
Huyet et al (2007) Structural basis of spirolactone recognition by the mineralocorticoid receptor. Mol.Pharmacol. 72 563 PMID: 17569793
Lazar and Agarwal (1986) Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists. Biochem.Biophy.Res.Comms. 134 261
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Keywords: RU 26752, RU 26752 supplier, Mineralocorticoid, receptors, antagonists, Aldosterone, RU26752, Receptor, 2970, Tocris Bioscience
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