RU 26752

Discontinued Product

RU 26752 (Cat. No. 2970) has been withdrawn from sale for commercial reasons.
Cat.No. 2970 - RU 26752 | C25H36O3 | CAS No. 76676-33-0
Description: Mineralocorticoid receptor antagonist
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid γ-lactone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Mineralocorticoid receptor antagonist. Prevents aldosterone-induced hypertension in rats.

Technical Data

M. Wt 384.55
Formula C25H36O3
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 76676-33-0
PubChem ID 9886385
InChI Key MOFIIHQCTIJVBB-JEHIOXJOSA-N
Smiles O=C1CC[C@@]2(C)C(C[C@@H](CCC)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Kalimi et al (1990) Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats. Am.J.Physiol. 258 E737 PMID: 2333987

Huyet et al (2007) Structural basis of spirolactone recognition by the mineralocorticoid receptor. Mol.Pharmacol. 72 563 PMID: 17569793

Lazar and Agarwal (1986) Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists. Biochem.Biophy.Res.Comms. 134 261

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Keywords: RU 26752, RU 26752 supplier, Mineralocorticoid, receptors, antagonists, Aldosterone, RU26752, Receptor, 2970, Tocris Bioscience

Citations for RU 26752

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Literature in this Area

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