(RS)-AMPA hydrobromide

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Description: Selective AMPA agonist; more water soluble form of (RS)-AMPA (Cat. No. 0169)
Chemical Name: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (5)

Biological Activity for (RS)-AMPA hydrobromide

(RS)-AMPA hydrobromide is a more water soluble hydrobromide salt of (RS)-AMPA (Cat. No. 0169).

Technical Data for (RS)-AMPA hydrobromide

M. Wt 267.08
Formula C7H10N2O4.HBr
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 171259-81-7
PubChem ID 11957558
InChI Key KUAHVIUZGLGASU-UHFFFAOYSA-N
Smiles Br.CC1=C(CC(N)C(O)=O)C(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (RS)-AMPA hydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.67 10 with gentle warming

Preparing Stock Solutions for (RS)-AMPA hydrobromide

The following data is based on the product molecular weight 267.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.44 mL 187.21 mL 374.42 mL
0.5 mM 7.49 mL 37.44 mL 74.88 mL
1 mM 3.74 mL 18.72 mL 37.44 mL
5 mM 0.75 mL 3.74 mL 7.49 mL

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Product Datasheets for (RS)-AMPA hydrobromide

Certificate of Analysis / Product Datasheet
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References for (RS)-AMPA hydrobromide

References are publications that support the biological activity of the product.

Honore et al (1982) The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes. J.Neurochem. 38 173 PMID: 6125564

Krogsgaard-Larsen et al (1980) New class of glutamate agonist structurally related to ibotenic acid. Nature 284 64 PMID: 6101908

Ko et al (2021) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 13 PMID: 33918958


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Keywords: (RS)-AMPA hydrobromide, (RS)-AMPA hydrobromide supplier, water, soluble, Glutamate, AMPA, Receptors, iGlur, Ionotropic, 1074, Tocris Bioscience

5 Citations for (RS)-AMPA hydrobromide

Citations are publications that use Tocris products. Selected citations for (RS)-AMPA hydrobromide include:

Wasling et al (2012) AMPA receptor activation causes silencing of AMPA receptor-mediated synaptic transmission in the developing hippocampus. PLoS One 7 e34474 PMID: 22485173

Pierrot et al (2019) Sex-regulated gene dosage effect of PPARα on synaptic plasticity. Life Sci Alliance 2 PMID: 30894406

Goo et al (2017) Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. J Cell Biol 216 2499 PMID: 28630145

Iskandrani et al (2015) Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons. J Neurosci 29 792 PMID: 25759403


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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