(RS)-AMPA hydrobromide

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Cat.No. 1074 - (RS)-AMPA hydrobromide | C7H10N2O4.HBr | CAS No. 171259-81-7
Description: Selective AMPA agonist; more water soluble form of (RS)-AMPA (Cat. No. 0169)
Chemical Name: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (10)

Biological Activity

More water soluble hydrobromide salt of (RS)-AMPA (Cat. No. 0169).

Technical Data

M. Wt 267.08
Formula C7H10N2O4.HBr
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 171259-81-7
PubChem ID 11957558
InChI Key KUAHVIUZGLGASU-UHFFFAOYSA-N
Smiles Br.CC1=C(CC(N)C(O)=O)C(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.67 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 267.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.44 mL 187.21 mL 374.42 mL
0.5 mM 7.49 mL 37.44 mL 74.88 mL
1 mM 3.74 mL 18.72 mL 37.44 mL
5 mM 0.75 mL 3.74 mL 7.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Honore et al (1982) The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes. J.Neurochem. 38 173 PMID: 6125564

Krogsgaard-Larsen et al (1980) New class of glutamate agonist structurally related to ibotenic acid. Nature 284 64 PMID: 6101908


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Keywords: (RS)-AMPA hydrobromide, (RS)-AMPA hydrobromide supplier, water, soluble, Glutamate, AMPA, Receptors, iGlur, Ionotropic, 1074, Tocris Bioscience

5 Citations for (RS)-AMPA hydrobromide

Citations are publications that use Tocris products. Selected citations for (RS)-AMPA hydrobromide include:

Iskandrani et al (2015) Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons. J Neurosci 29 792 PMID: 25759403

Pierrot et al (2019) Sex-regulated gene dosage effect of PPARα on synaptic plasticity. Life Sci Alliance 2 PMID: 30894406

Goo et al (2017) Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. J Cell Biol 216 2499 PMID: 28630145

Chanda et al (2013) Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. J Psychopharmacol 110 16622 PMID: 24046374


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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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