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More water soluble hydrobromide salt of (RS)-AMPA (Cat. No. 0169).
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||2.67||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 267.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||37.44 mL||187.21 mL||374.42 mL|
|0.5 mM||7.49 mL||37.44 mL||74.88 mL|
|1 mM||3.74 mL||18.72 mL||37.44 mL|
|5 mM||0.75 mL||3.74 mL||7.49 mL|
References are publications that support the biological activity of the product.
Honore et al (1982) The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes. J.Neurochem. 38 173 PMID: 6125564
Krogsgaard-Larsen et al (1980) New class of glutamate agonist structurally related to ibotenic acid. Nature 284 64 PMID: 6101908
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Keywords: (RS)-AMPA hydrobromide, (RS)-AMPA hydrobromide supplier, water, soluble, Glutamate, AMPA, Receptors, iGlur, Ionotropic, 1074, Tocris Bioscience
5 Citations for (RS)-AMPA hydrobromide
Citations are publications that use Tocris products. Selected citations for (RS)-AMPA hydrobromide include:
Iskandrani et al (2015) Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons. J Neurosci 29 792 PMID: 25759403
Pierrot et al (2019) Sex-regulated gene dosage effect of PPARα on synaptic plasticity. Life Sci Alliance 2 PMID: 30894406
Goo et al (2017) Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. J Cell Biol 216 2499 PMID: 28630145
Chanda et al (2013) Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. J Psychopharmacol 110 16622 PMID: 24046374
Wasling et al (2012) AMPA receptor activation causes silencing of AMPA receptor-mediated synaptic transmission in the developing hippocampus. PLoS One 7 e34474 PMID: 22485173
Do you know of a great paper that uses (RS)-AMPA hydrobromide from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.