RS 56812 hydrochloride

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Cat.No. 0988 - RS 56812 hydrochloride | C18H21N3O2.HCl | CAS No. 143339-12-2
Description: 5-HT3 partial agonist
Chemical Name: (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

A highly potent and selective 5-HT3 partial agonist, with a pKi at 5-HT3 receptors in rat brain of 9.6, and greater than 1000-fold selectivity over a wide range of other neurotransmitter receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt 347.84
Formula C18H21N3O2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 143339-12-2
PubChem ID 67858205
InChI Key NHWCYXITJPBOHX-RSAXXLAASA-N
Smiles O=C(C(N[C@@H]3C(CC4)CCN4C3)=O)C1=CN(C)C2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 34.78 100
DMSO 17.39 50
water 34.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 347.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.37 mL 28.75 mL
5 mM 0.57 mL 2.87 mL 5.75 mL
10 mM 0.29 mL 1.44 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Clark et al (1995) N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide: a high affinity 5-HT3 receptor partial agonist. Bioorg.Med.Chem.Lett. 5 1853 PMID:


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Keywords: RS 56812 hydrochloride, supplier, 5-HT3, partial, agonists, Serotonin, Receptors, RS56812, hydrochloride, 5-HT3, Receptors, Tocris Bioscience

1 Citation for RS 56812 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 56812 hydrochloride include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Mol Psychiatry 7 2336 PMID: 26114334


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Reviews

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for RS 56812 hydrochloride

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