RS 56812 hydrochloride

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Cat.No. 0988 - RS 56812 hydrochloride | C18H21N3O2.HCl | CAS No. 143339-12-2
Description: 5-HT3 partial agonist
Chemical Name: (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for RS 56812 hydrochloride

RS 56812 hydrochloride is a highly potent and selective 5-HT3 partial agonist, with a pKi at 5-HT3 receptors in rat brain of 9.6, and greater than 1000-fold selectivity over a wide range of other neurotransmitter receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 56812 hydrochloride

M. Wt 347.84
Formula C18H21N3O2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 143339-12-2
PubChem ID 67858205
InChI Key NHWCYXITJPBOHX-RSAXXLAASA-N
Smiles O=C(C(N[C@@H]3C(CC4)CCN4C3)=O)C1=CN(C)C2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RS 56812 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 34.78 100
DMSO 17.39 50

Preparing Stock Solutions for RS 56812 hydrochloride

The following data is based on the product molecular weight 347.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.37 mL 28.75 mL
5 mM 0.57 mL 2.87 mL 5.75 mL
10 mM 0.29 mL 1.44 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets for RS 56812 hydrochloride

References for RS 56812 hydrochloride

References are publications that support the biological activity of the product.

Clark et al (1995) N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide: a high affinity 5-HT3 receptor partial agonist. Bioorg.Med.Chem.Lett. 5 1853


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1 Citation for RS 56812 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 56812 hydrochloride include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Mol Psychiatry 7 2336 PMID: 26114334


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Literature in this Area

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.