(RS)-5-Bromowillardiine

Discontinued Product

Unfortunately (RS)-5-Bromowillardiine (Cat. No. 0132) has been withdrawn from sale for commercial reasons.
Cat.No. 0132 - (RS)-5-Bromowillardiine | CAS No. 20698-16-2
Description: Potent AMPA / kainate agonist
Chemical Name: (RS)-a-Amino-5-bromo-3,4-dihydro-2,4-dioxo-1(2H)pyridinepropanoic acid
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent excitant at non-NMDA receptors. More active than kainate at C-fibre kainate receptors. See separate isomers 0303 and 0304.

Technical Data

M. Wt 278.06
Storage Store at RT
CAS Number 20698-16-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 278.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.6 mL 17.98 mL 35.96 mL
5 mM 0.72 mL 3.6 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.6 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet

References

References are publications that support the products' biological activity.

Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345 PMID: 3513882

Davies et al (1982) Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous system. Comp.Biochem.Physiol. 72 211 PMID: 6128141

Davies et al (1983) Recent advances in the pharmacology of excitatory amino acids in the mammalian central nervous system. Wenner-Gren Symposium on Excitotoxins. Edited by F 43-54 PMID:

View Related Products by Target

View Related Products by Product Action

View all Kainate Receptor Agonists

Keywords: (RS)-5-Bromowillardiine, supplier, Kainate, Receptors, Kainate, Receptors, Tocris Bioscience

Citations for (RS)-5-Bromowillardiine

Citations are publications that use Tocris products.

Currently there are no citations for (RS)-5-Bromowillardiine.

Reviews for (RS)-5-Bromowillardiine

There are currently no reviews for this product. Be the first to review (RS)-5-Bromowillardiine and earn rewards!

Have you used (RS)-5-Bromowillardiine?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Learning & Memory

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.