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Discontinued Product(RS)-5-Bromowillardiine (Cat. No. 0132) has been withdrawn from sale for commercial reasons.
Potent excitant at non-NMDA receptors. More active than kainate at C-fibre kainate receptors. See separate isomers 0303 and 0304.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345 PMID: 3513882
Davies et al (1982) Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous system. Comp.Biochem.Physiol. 72 211 PMID: 6128141
Davies et al (1983) Recent advances in the pharmacology of excitatory amino acids in the mammalian central nervous system. Wenner-Gren Symposium on Excitotoxins. Edited by F 43-54
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Keywords: (RS)-5-Bromowillardiine, (RS)-5-Bromowillardiine supplier, Kainate, Receptors, 0132, Tocris Bioscience
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Literature in this Area
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.