RS 45041-190 hydrochloride

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Cat.No. 0889 - RS 45041-190 hydrochloride | C11H12ClN3.HCl | CAS No. 204274-74-8
Description: High affinity I2 ligand. Highly selective
Chemical Name: 4-Chloro-2-(imidazolin-2-yl)isoindoline hydrochloride
Citations (1)

Biological Activity

Highly selective I2 imidazoline receptor ligand.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt 258.15
Formula C11H12ClN3.HCl
Storage Store at RT
CAS Number 204274-74-8
PubChem ID 10332716
Smiles Cl.ClC1=C2CN(CC2=CC=C1)C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 258.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.87 mL 19.37 mL 38.74 mL
5 mM 0.77 mL 3.87 mL 7.75 mL
10 mM 0.39 mL 1.94 mL 3.87 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References are publications that support the biological activity of the product.

Brown et al (1995) RS-45041-190: a selective, high affinity ligand for I2 imidazoline receptors. Br.J.Pharmacol. 116 1737 PMID: 8528553

Jett et al (1999) Behavioral effects of RS-45041-190, a selective I2 imidazoline ligand in rats. Ann.N.Y.Acad.Sci. 881 369 PMID: 10415939

If you know of a relevant reference for RS 45041-190 hydrochloride, please let us know.

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1 Citation for RS 45041-190 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 45041-190 hydrochloride include:

Mockel et al (2012) Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability. J Biol Chem 287 37483 PMID: 22869374

Do you know of a great paper that uses RS 45041-190 hydrochloride from Tocris? Please let us know.

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