RS 25344 hydrochloride
Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 411.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.43 mL||12.14 mL||24.28 mL|
|5 mM||0.49 mL||2.43 mL||4.86 mL|
|10 mM||0.24 mL||1.21 mL||2.43 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References are publications that support the biological activity of the product.
Alvarez et al (1995) Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol.Pharmacol. 48 616 PMID: 7476886
Kaneko et al (1995) Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell.Signal. 7 527 PMID: 8562314
Bajpai et al (2006) AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Biol.Reprod. 74 109 PMID: 16177223
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Keywords: RS 25344 hydrochloride, RS 25344 hydrochloride supplier, RS25344, potent, PDE4, inhibitors, inhibits, phosphodiesterases, Phosphodiesterases, 3315, Tocris Bioscience
1 Citation for RS 25344 hydrochloride
Citations are publications that use Tocris products. Selected citations for RS 25344 hydrochloride include:
Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. Cell Rep 171 2385 PMID: 24467222
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