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(RS)-2-Hydroxyglutaric acid disodium salt

Cat. No. 6122 Submit a Review Datasheet / COA / SDS
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Description: Metabolite
Chemical Name: (RS)-2-Hydroxypentanedioic acid disodium salt
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Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

(RS)-2-Hydroxyglutaric acid disodium salt is an oncometabolite with R- and S- enantiomers overproduced in the neurometabolic disease 2-hydroxyglutaric aciduria (2-HGA).

Technical Data

M. Wt 192.08
Formula C5H6Na2O5
Storage Store at -20°C
CAS Number 40951-21-1
PubChem ID 134081824
InChI Key DZHFTEDSQFPDPP-UHFFFAOYSA-L
Smiles OC(C(O[Na])=O)CCC(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 192.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.21 mL 26.03 mL 52.06 mL
5 mM 1.04 mL 5.21 mL 10.41 mL
10 mM 0.52 mL 2.6 mL 5.21 mL
50 mM 0.1 mL 0.52 mL 1.04 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Du and Hu (2021) The roles of 2-Hydroxyglutarate. Front.Cell Dev.Biol. 9 651317 PMID: 33842477

If you know of a relevant reference for (RS)-2-Hydroxyglutaric acid disodium salt, please let us know.

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Citations for (RS)-2-Hydroxyglutaric acid disodium salt

Citations are publications that use Tocris products.

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