RS 16566 dihydrochloride

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Cat.No. 1015 - RS 16566 dihydrochloride | C18H23ClN4O.2HCl | CAS No. 1217788-97-0
Description: 5-HT3 ligand. Also shows affinity for zacopride binding site
Chemical Name: (R)-N-1-Azabicyclo[2.2.2]oct-3-yl-6-chloro-1-(1-methylethyl)-1H-benzimidazole-4-carboxamide
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

High affinity ligand for the (R)-zacopride binding site (pKi 9.84 ).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt 419.78
Formula C18H23ClN4O.2HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1217788-97-0
PubChem ID 90479748
Smiles ClC1=CC(C(N[C@@H]3C4CCN(CC4)C3)=O)=C2C(N(C(C)C)C=N2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 4.2 10
phosphate buffered saline 4.2 10

Preparing Stock Solutions

The following data is based on the product molecular weight 419.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.91 mL 23.82 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Flippin et al (1996) (R)-3-(6-Chloro-1-isopropylbenzimidazole-4-carboxamido)quinuclidine: a high affinity ligand for the (R)-zacopride binding site. Bioorg.Med.Chem.Lett. 6 477 PMID:

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1 Citation for RS 16566 dihydrochloride

Citations are publications that use Tocris products. Selected citations for RS 16566 dihydrochloride include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. J Neurosci 7 2336 PMID: 26114334

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.