RS 09

Pricing Availability Delivery Time Qty
Cat.No. 5928 - RS 09 | Ala-Pro-Pro-His-Ala-Leu-Ser | CAS No. 1449566-36-2
Description: TLR4 peptide agonist; acts as an adjuvant in vivo
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.

Technical Data

M. Wt 691.78
Formula C31H49N9O9
Sequence APPHALS
Storage Store at -20°C
CAS Number 1449566-36-2
PubChem ID 121513902
InChI Key SHYNPSTXGFDOBD-HRALPVODSA-N
Smiles [H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 691.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.45 mL 7.23 mL 14.46 mL
5 mM 0.29 mL 1.45 mL 2.89 mL
10 mM 0.14 mL 0.72 mL 1.45 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Li et al (2016) Intranasal vaccination against HIV-1 with adenoviral vector-based nanocomplex using synthetic TLR-4 agonist peptide as adjuvant. Mol.Pharm. 13 885 PMID: 26824411

Shanmugam et al (2012) Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants. PLoS One 7 e30839 PMID: 22363498


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Keywords: RS 09, RS 09 supplier, RS09, TLR4, peptides, agonists, toll-like, receptors, agonism, adjuvants, Toll-like, Receptors, 5928, Tocris Bioscience

Citations for RS 09

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Literature in this Area

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Pathways for RS 09

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.