RS 09

Discontinued Product

RS 09 (Cat. No. 5928) has been withdrawn from sale for commercial reasons.
Description: TLR4 peptide agonist; acts as an adjuvant in vivo
Pathways (1)

Biological Activity for RS 09

RS 09 is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.

Technical Data for RS 09

M. Wt 691.78
Formula C31H49N9O9
Sequence APPHALS
Storage Store at -20°C
CAS Number 1449566-36-2
PubChem ID 121513902
Smiles [H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RS 09

Certificate of Analysis / Product Datasheet
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References for RS 09

References are publications that support the biological activity of the product.

Li et al (2016) Intranasal vaccination against HIV-1 with adenoviral vector-based nanocomplex using synthetic TLR-4 agonist peptide as adjuvant. Mol.Pharm. 13 885 PMID: 26824411

Shanmugam et al (2012) Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants. PLoS One 7 e30839 PMID: 22363498

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Keywords: RS 09, RS 09 supplier, RS09, TLR4, peptides, agonists, toll-like, receptors, agonism, adjuvants, Toll-like, Receptors, 5928, Tocris Bioscience

Citations for RS 09

Citations are publications that use Tocris products.

Currently there are no citations for RS 09.

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Pathways for RS 09

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.