Selective D2-like receptor agonist (D3 > D2 > D4). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays antiParkinsonian activity.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 296.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.37 mL||16.84 mL||33.69 mL|
|5 mM||0.67 mL||3.37 mL||6.74 mL|
|10 mM||0.34 mL||1.68 mL||3.37 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Eden et al (1991) Preclinical pharmacology of Ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol.Biochem.Behav. 38 147 PMID: 1673248
Tulloch (1997) Pharmacologic profile of ropinirole: a nonergoline dopamine agonist. Neurology 49 S58 PMID: 9222275
If you know of a relevant reference for Ropinirole, please let us know.
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Keywords: Selective D2-like agonists non-selective dopamine receptors dopaminergic Non-selective Dopamine
Citations for Ropinirole
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Literature in this Area
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.