Ropinirole

Pricing Availability   Qty
Description: Selective D2-like agonist
Chemical Name: 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for Ropinirole

Ropinirole is a selective D2-like receptor agonist (D3 > D2 > D4). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays anti-Parkinsonian activity.

Technical Data for Ropinirole

M. Wt 296.84
Formula C16H24N2O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 91374-20-8
PubChem ID 68727
InChI Key XDXHAEQXIBQUEZ-UHFFFAOYSA-N
Smiles O=C2NC1=CC=CC(CCN(CCC)CCC)=C1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ropinirole

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.68 100
DMSO 14.84 50

Preparing Stock Solutions for Ropinirole

The following data is based on the product molecular weight 296.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.84 mL 33.69 mL
5 mM 0.67 mL 3.37 mL 6.74 mL
10 mM 0.34 mL 1.68 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets for Ropinirole

Certificate of Analysis / Product Datasheet
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References for Ropinirole

References are publications that support the biological activity of the product.

Eden et al (1991) Preclinical pharmacology of ropin. (SK&F 101468-A) a novel DA D2 agonist. Pharmacol.Biochem.Behav. 38 147 PMID: 1673248

Tulloch (1997) Pharmacologic profile of ropinirole: a nonergoline DA agonist. Neurology 49 S58 PMID: 9222275


If you know of a relevant reference for Ropinirole, please let us know.

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Keywords: Ropinirole, Ropinirole supplier, Selective, D2-like, agonists, non-selective, dopamine, receptors, dopaminergic, Non-selective, Dopamine, 3680, Tocris Bioscience

1 Citation for Ropinirole

Citations are publications that use Tocris products. Selected citations for Ropinirole include:

Stefan et al (2021) New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Sci Rep 11 8288 PMID: 33859231


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Reviews for Ropinirole

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.