Ro 26-4550 trifluoroacetate

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Cat.No. 1794 - Ro 26-4550 trifluoroacetate | C26H30N4O3.CF3CO2H | CAS No. 1217448-66-2
Description: Competitive inhibitor of IL-2/ IL-2Rα receptor interaction
Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate
Purity: ≥98% (HPLC)

Biological Activity

Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.

Technical Data

M. Wt 560.57
Formula C26H30N4O3.CF3CO2H
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 1217448-66-2
PubChem ID 16760522
Smiles FC(F)(F)C(O)=O.NC(N1CCC[C@H](CC(N[C@H](C(OC)=O)CC2=CC=C(C#CC3=CC=CC=C3)C=C2)=O)C1)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.03 50
ethanol 2.8 5

Preparing Stock Solutions

The following data is based on the product molecular weight 560.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.57 mL 17.84 mL 35.68 mL
2.5 mM 0.71 mL 3.57 mL 7.14 mL
5 mM 0.36 mL 1.78 mL 3.57 mL
25 mM 0.07 mL 0.36 mL 0.71 mL

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References are publications that support the biological activity of the product.

Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714 PMID: 12656598

Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589

If you know of a relevant reference for Ro 26-4550 trifluoroacetate, please let us know.

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