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Ro 26-4550 trifluoroacetate
Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 560.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.57 mL||17.84 mL||35.68 mL|
|2.5 mM||0.71 mL||3.57 mL||7.14 mL|
|5 mM||0.36 mL||1.78 mL||3.57 mL|
|25 mM||0.07 mL||0.36 mL||0.71 mL|
References are publications that support the biological activity of the product.
Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714 PMID: 12656598
Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589
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Citations for Ro 26-4550 trifluoroacetate
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.