Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRo 1138452 hydrochloride is a selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable.
Ro 1138452 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 345.87 |
Formula | C19H23N3O.HCl |
Storage | Desiccate at RT |
Purity | ≥98% (HPLC) |
PubChem ID | 91826074 |
InChI Key | OYPSAMWVIBGRMV-UHFFFAOYSA-N |
Smiles | CC(C)OC1=CC=C(CC2=CC=C(NC3=NCCN3)C=C2)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 34.59 | 100 | |
DMSO | 34.59 | 100 |
The following data is based on the product molecular weight 345.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.89 mL | 14.46 mL | 28.91 mL |
5 mM | 0.58 mL | 2.89 mL | 5.78 mL |
10 mM | 0.29 mL | 1.45 mL | 2.89 mL |
50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
References are publications that support the biological activity of the product.
Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053 PMID: 15013022
Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. Br.J.Pharmacol. 149 110 PMID: 16880763
Bley et al (2006) RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br.J.Pharmacol. 147 335 PMID: 16331286
If you know of a relevant reference for Ro 1138452 hydrochloride, please let us know.
Keywords: Ro 1138452 hydrochloride, Ro 1138452 hydrochloride supplier, Ro1138452, hydrochloride, supplier, IP, receptors, antagonists, prostanoid, prostaglandins, prostacyclins, eicosanoids, analgesic, CAS, 221529-58-4, Prostanoid, Receptors, 4268, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Ro 1138452 hydrochloride. Do you know of a great paper that uses Ro 1138452 hydrochloride from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review Ro 1138452 hydrochloride and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.