RMR-Tre

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Description: Far-red fluorogenic trehalose probe for live mycobacteria imaging
Chemical Name: 3-(6-(5-(2,2-Dicyanovinyl)thiophen-2-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-(((2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl)propanamide
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for RMR-Tre

RMR-Tre is a far-red fluorogenic trehalose specific probe for live mycobacteria imaging. It enables fast, no-wash, low-background fluorescence detection of live mycobacterial outer membrane. RMR-Tre contains a molecular rotor fluorophore that brightly emits signal in the far-red region upon trehalose-guided metabolic integration into the mycomembrane. It exhibited up to a 100- fold enhancement in Mycobacterium tuberculosis labeling compared to existing fluorogenic trehalose probes. Excitation and emission maxima (λ) are 549 nm and 571 nm, respectively.

Scientific Data

Fluorescence Imaging Far-red fluorogenic trehalose probe for live mycobacteria imaging View Larger

Application of RMR-Tre. Image shows fluorescence detection of live mycobacterial outer membrane: M. smegmatis were incubated for 1 h in the presence of 100 μM of RMR-Tre, then directly imaged by fluorescence microscopy without washing. Scale bar: 10 μm.

Licensing Information

Sold under license from Central Michigan University

Optical Data for RMR-Tre

RMR-Tre Dye Spectra
Emission Color Far Red
λabs 536 nm
λem 684 nm
Closest Laser line 540 nm

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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Technical Data for RMR-Tre

M. Wt 686.73
Formula C32H38N4O11S
Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key SSAVIDOUSMJZDG-IVJDZZAPSA-N
Smiles O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]1CO)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CNC(CCN3C4=C(CCC3)C=C(C5=CC=C(S5)/C=C(C#N)/C#N)C=C4)=O)O)O)O)O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RMR-Tre

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.87 10

Preparing Stock Solutions for RMR-Tre

The following data is based on the product molecular weight 686.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.56 mL 72.81 mL 145.62 mL
0.5 mM 2.91 mL 14.56 mL 29.12 mL
1 mM 1.46 mL 7.28 mL 14.56 mL
5 mM 0.29 mL 1.46 mL 2.91 mL

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References for RMR-Tre

References are publications that support the biological activity of the product.

Banahene et al (2023) A far-red molecular rotor fluorogenic trehalose probe for live mycobacteria detection and drug-susceptibility testing. Angew.Chem.Int.Ed.Engl. 62 e202213563 PMID: 36346622


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Keywords: RMR-Tre, RMR-Tre supplier, fluorescent, labeling, bacteria, labels, labelling, red, probes, for, imaging, trehalose, live, mycobacteria, fluorophore, Fluorescent, Probes, Imaging, Bacteria, 8013, Tocris Bioscience

Citations for RMR-Tre

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Literature in this Area

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