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Description: Far-red fluorogenic trehalose probe for live mycobacteria imaging
Chemical Name: 3-(6-(5-(2,2-Dicyanovinyl)thiophen-2-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-(((2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl)propanamide
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for RMR-Tre

RMR-Tre is a far-red fluorogenic trehalose specific probe for live mycobacteria imaging. It enables fast, no-wash, low-background fluorescence detection of live mycobacterial outer membrane. RMR-Tre contains a molecular rotor fluorophore that brightly emits signal in the far-red region upon trehalose-guided metabolic integration into the mycomembrane. It exhibited up to a 100- fold enhancement in Mycobacterium tuberculosis labeling compared to existing fluorogenic trehalose probes. Excitation and emission maxima (λ) are 549 nm and 571 nm, respectively.

Scientific Data

Fluorescence Imaging Far-red fluorogenic trehalose probe for live mycobacteria imaging View Larger

Application of RMR-Tre. Image shows fluorescence detection of live mycobacterial outer membrane: M. smegmatis were incubated for 1 h in the presence of 100 μM of RMR-Tre, then directly imaged by fluorescence microscopy without washing. Scale bar: 10 μm.

Licensing Information

Sold under license from Central Michigan University

Optical Data for RMR-Tre

RMR-Tre Dye Spectra
Emission Color Far Red
λabs 536 nm
λem 684 nm
Closest Laser line 540 nm

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Technical Data for RMR-Tre

M. Wt 686.73
Formula C32H38N4O11S
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]1CO)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CNC(CCN3C4=C(CCC3)C=C(C5=CC=C(S5)/C=C(C#N)/C#N)C=C4)=O)O)O)O)O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RMR-Tre

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.87 10

Preparing Stock Solutions for RMR-Tre

The following data is based on the product molecular weight 686.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.56 mL 72.81 mL 145.62 mL
0.5 mM 2.91 mL 14.56 mL 29.12 mL
1 mM 1.46 mL 7.28 mL 14.56 mL
5 mM 0.29 mL 1.46 mL 2.91 mL

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References for RMR-Tre

References are publications that support the biological activity of the product.

Banahene et al (2023) A far-red molecular rotor fluorogenic trehalose probe for live mycobacteria detection and drug-susceptibility testing. Angew.Chem.Int.Ed.Engl. 62 e202213563 PMID: 36346622

If you know of a relevant reference for RMR-Tre, please let us know.

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Citations for RMR-Tre

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Literature in this Area

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Fluorescent Dyes and Probes Research Product Guide

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